维持性血液透析患者脂质代谢紊乱与心脑血管事件关系的临床研究-东南大学学报医学版

维持性血液透析患者脂质代谢紊乱与心脑血管事件关系的临床研究

单位：东南大学附属中大医院肾脏病研究所, 江苏南京 210009

分类号：R589.2

出版年·卷·期（页码）：2012·31·第六期（720-724）

摘要：

目的:探讨维持性血液透析(MHD)患者脂质代谢紊乱与心脑血管事件发生的关系。方法:根据是否发生心脑血管事件将MHD患者分为心脑血管事件组及非心脑血管事件组,对两组脂代谢指标进行比较,分析MHD患者发生心脑血管事件的危险因素。结果:MHD患者的脂代谢紊乱主要表现为载脂蛋白A1及高密度脂蛋白降低、脂蛋白(a)及低密度脂蛋白和甘油三酯升高。与非心脑血管事件组比较,心脑血管事件组脂质谱改变主要表现为甘油三酯升高(P<0.05)。多因素分析结果显示,年龄、透析时间、透析时超滤量、糖尿病、甘油三酯是MHD患者心脑血管事件发生的重要危险因素。结论:发生心脑血管事件的MHD患者脂质谱改变主要是甘油三酯升高;年龄、糖尿病、透析时间、透析时超滤量、甘油三酯可能是MHD患者心脑血管事件发生的重要危险因素。

Objective:To investigate the relationship between lipid metabolism disorders and cardiocerebrovascular events in the patients with maintenance hemodialysis (MHD). Methods: The MHD patients were divided into two groups according to happened cardiocerebrovascular events or not,and the differences of lipid metabolism indicators between the two groups was compared. The dangerous factors of cardiocerebrovascular events in patients with MHD were analyzed. Results: The lipid metabolism disorders of MHD patients desmonted as decreased apolipoprotein A1,high-density lipoprotein and increased lipoprotein (a),low density lipoprotein and triglyceride. Compared with patients without cardiocerebrovascular events,triglyceride was increased. The age,dialysis duration,dialysis ultrafiltration volume,diabetes mellitus history,TG were important risk factors of cardiocerebrovascular events for MHD patients. Conclusions: The main change of dislipidemia in MHD patients with cardiocerebrovascular events is TG increased. The age,diabetes mellitus history,dialysis duration,dialysis ultrafiltration volume,TG are important risk factors of cardiocerebrovascular events for MHD patients.

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