Objective: To investigate the application value of air-fluidized bed in treatment of severe burn patients. Methods: After debridement 30 patients with severe burn lying on common sickbed(common sickbed group) and 30 patients with severe burn lying on air-fluidized bed(air-fluidized bed group) were chosen randomdly.The scabbing time,concrescence time,burn wound infection and sheet bacterial content were compared between the two groups. Results: Scabbing time and concrescence time in common sickbed group were (164.8±4.54) h and (55.17±0.88) d respectively,and those in air-fluidized bed group were (84.67±3.11) h and (28.62±0.58) d respectively. The differences had statistical significance(P<0.01).Positive rate of bacterial culture was 43.3% in common sickbed gruop,which was much higher than that(16.7%) in air-fluidized bed group (P<0.01). Conclusions: Application of air-fluidized bed could effectively protect burn wound,and relieve the suffering of severe burn patients, and cut down difficulty of nursing.Consequently,it has positive value in treatment severe burn patients.