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听觉皮层网络老化的静息态功能磁共振成像研究
作者:朱新 黄志纯 刘斌 
单位:东南大学附属中大医院
关键词:听觉皮层  静息态 功能连接 
分类号:
出版年·卷·期(页码):2012·31·第五期(577-581)
摘要:

目的:利用静息态MRI功能连接的方法观察正常青年人与中老年人听觉皮层与脑的正相关的功能连接,观察不同年龄间的差异。方法: 选取正常青年人与中老年人各30例进行静息态功能MRI数据采集,用功能连接的方法分别观察左右大脑听觉皮层与脑区不同的正相关功能连接脑图, 并比较其差异。结果: 30例青年受试者分别以双侧AⅠ区为种子点时,正激活的脑网络主要包含双侧颞横回、颞上回、岛叶、前扣带回及辅助运动区。30例中老年组受试者分别以双侧AⅠ区为种子点时,正激活的脑网络与青年组类似,但是仍有差别,主要存在于岛叶、扣带回及辅助运动区。结论:青年组与中老年组以以双侧AⅠ区为种子点的听觉系统的功能连接均主要局限于听觉系统之内,老化可对该网络产生影响。

Objective: resting state functional connectivity MRI to observe the normal auditory cortex of young people and the elderly are associated with brain functional connectivity, the differences observed between different age groups. Methods: normal young and the elderly of 30 patients were resting state functional MRI data acquisition, connected with the function of the method were observed in left and right cerebral cortex and the auditory brain areas are related to functional connectivity of different brain map, and compare their differences. Results: 30 cases were in young subjects with bilateral AⅠ areas of the seed point, the brain is activated bilateral temporal network consists mainly of cross-back, superior temporal gyrus, anterior cingulate gyrus, insular cortex, supplementary motor area. Middle-aged group of 30 subjects, respectively, the effective data area of the bilateral A Ⅰ seed point, are activated similar brain networks with the young group, but there are still differences, mainly in the insula, cingulate gyrus and supplementary motor area. Conclusion: young group and in the older group to the bilateral seed point AⅠareas of the auditory function of the system connections are mainly confined withinthe auditory system, aging can affect the network.

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