ABSTRACT: Objective: To analyze the clinical and epidemiological characteristics of 6 cases with SFTSV Infection of Lishui County in 2011, so as to provide reference for making prevention and control measures. Methods: Investigating cases by uniform diagnostic criteria and epidemiological questionnaire of the Ministry of Health. Results: The incidence rate of disease was 1.42 per 100 thousand, the mortality rate was 0.24 per 100 thousand. The clinical manifestations including fever (6 cases), fatigue (6 cases), loss of appetite (6 cases), muscular stiffness (5 cases), diarrhea (5 cases), and nausea (4 cases). Laboratory results including thrombocytopenia and leucopenia (6 cases), elevated AST (6 cases), CPK (6 cases), LDH (6 cases),a-HBDH (5 cases), CK-MB(5 cases), Cystatin (5 cases). All cases were elderly people from Qiuling Town, and occurred between April to July. There was premorbid history of tick bites in some cases. Conclusions: The clinical symptoms of SFTSV cases were atypical in the early onset. Regional and highly sporadic features were observed. The residents of the hilly area of life, production had a higher risk of infection.