[1] KOJIMA M,HOSODA H,DATE Y,et al.Ghrelin is a growth-hormone-releasing acylated peptide from stomach[J].Nature,1999,402(6762):656-660.
[2] KOJIMA M,KANGAWA K.Ghrelin: structure and function[J].Physiol Rev,2005,85(2):495-522.
[3] YANG J,BROWN M S,LIANG G,et al.Identification of the acyltransferase that octanoylates ghrelin,an appetite-stimulating peptide hormone[J].Cell,2008,132(3):387-396.
[4] KAMEGAI J,TAMURA H,SHIMIZU T,et al.The role of pituitary ghrelin in growth hormone(GH) secretion:GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content[J].Endocrinology,2004,145(8):3731-3738.
[5] SMITH R G,JIANG H,SUN Y.Developments in ghrelin biology and potential clinical relevance[J].Trends Endocrinol Metab,2005,16(9):436-442.
[6] KATUGAMPOLA S D,KUC R E,MAGUIRE J J,et al.G-protein-coupled receptors in human atherosclerosis:comparison of vasoconstrictors(endothelin and thromboxane) with recently de-orphanized (urotensin-Ⅱ,apelin and ghrelin) receptors[J].Clin Sci(Lond),2002,103(Suppl 48):S171-S175.
[7] KORBONITS M,GOLDSTONE A P,GUEORGUIEV M,et al.Ghrelin-a hormone with multiple functions[J].Front Neuroendocrinol,2004,25(1):27-68.
[8] LANFRANCO F,MOTTA G,BALDI M,et al.Ghrelin and anterior pituitary function[J].Front Horm Res,2010,38:206-211.
[9] PAZOS Y,CASANUEVA F F,CAMINA J P.Basic aspects of ghrelin action[J].Vitam Horm,2008,77:89-119.
[10] COWLEY M A,GROVE K L.Ghrelin—satisfying a hunger for the mechanism[J].Endocrinology,2004,145(6):2604-2606.
[11] MAGER U,KOLEHMAINEN M,LINDSTROM J,et al.Association between ghrelin gene variations and blood pressure in subjects with impaired glucose tolerance[J].Am J Hypertens,2006,19(9):920-926.
[12] IANTORNO M,CHEN H,KIM J A,et al.Ghrelin has novel vascular actions that mimic PI3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells.[J].Am J Physiol Endocrinol Metab,2007,292:E756-764.
[13] LI W G,GAVRILA D,LIU X,et al.Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells[J].Circulation,2004,109(18):2221-2226.
[14] MOAZED B,QUEST D,GOPALAKRISHNAN V.Des-acyl ghrelin fragments evoke endothelium-dependent vasodilatation of rat mesenteric vascular bed via activation of potassium channels[J].Eur J Pharmacol,2009,604(1-3):79-86.
[15] 田利民,高翠霞,许衍甲,等.2型糖尿病患者瘦素、生长激素释放肽与胰岛素抵抗的相关性研究[J].临床内科杂志,2007,24(2):112-114.
[16] ASHRAF A,MICK G,MELETH S,et al.Insulin treatment reduces pre-prandial plasma ghrelin concentrations in children with type 1 diabetes[J].Med Sci Monit,2007,13(12):CR533-537.
[17] ZHANG W,CHAI B,LI J Y,et al.Effect of des-acyl ghrelin on adiposity and glucose metabolism[J].Endocrinology,2008,149(9):4710-4716.
[18] GAUNA C,KIEWIET R M,JANSSEN J A,et al.Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions[J].Am J Physiol Endocrinol Metab,2007,293(3):E697-704.
[19] GRANATA R,SETTANNI F,JULIEN M,et al.Des-Acyl Ghrelin fragments and analogues promote survival of pancreatic beta-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats[J].J Med Chem,2012,55(6):2585-2596.
[20] GAUNA C,van der LELY A J.Somatostatin,cortistatin,ghrelin and glucose metabolism[J].J Endocrinol Invest,2005,28(11 Suppl International):127-131.
[21] BARAZZONI R,ZANETTI M,FERREIRA C,et al.Relationships between des acylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome[J].Am J Physiol Endocrinol Metab,2007,92(10):3935-3940.
[22] BARAZZONI R,BOSUTTI A,STEBEL M,et al.Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle[J].Am J Physiol Endocrinol Metab,2005,288(1):E228-235.
[23] NOGUEIRA J P,MARANINCHI M,BELIARD S,et al.Unacylated ghrelin is associated with the isolated low HDL-cholesterol obese phenotype independently of insulin resistance and CRP level[J].Nutr Metab(Lond),2012,9(1):17.
[24] BENEDIX F,WESTPHAL S,PATSCHKE R,et al.Weight loss and changes in salivary ghrelin and adiponectin:comparison between sleeve gastrectomy and Roux-en-Y gastric bypass and gastric banding[J].Obes Surg,2011,21(5):616-624.
[25] CEDERBERG H,RAJALA U,KOIVISTO V M,et al.Unacylated ghrelin is associated with changes in body composition and body fat distribution during long-term exercise intervention[J].Eur J Endocrinol,2011,165(2):243-248.
[26] TIGNO X T,SELARU I K,ANGELONI S V,et al.Is microvascular flow rate related to ghrelin,leptin and adiponectin levels?[J].Clin Hemorheol Microcirc,2003,29(3-4):409-416.
[27] AVALLONE R D A,RODRIGUE-WAY A,BUJOLD K,et al.A growth hormone-releasing peptide that binds scavenger receptor CD36 and ghrelin receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome proliferator-activated receptor gamma-dependent pathway[J].Mol Endocrinol,2006,20(12):3165-3178.
[28] HU C Z,CAO Y L,HUO H Y,et al.Inhibitory effect of ghrelin on nicotine-induced VCAM-1 expression in human umbilical vein endothelial cells[J].J Cardiovasc Pharmacol,2009,53(3):241-245.
[29] TESAURO M,SCHINZARI F,IANTORNO M,et al.Ghrelin improves endothelial function in patients with metabolic syndrome[J].Circulation,2005,112(19):2986-2992. |
