血清总胆红素动态变化对新生儿心肌酶的影响-东南大学学报医学版

血清总胆红素动态变化对新生儿心肌酶的影响

单位：南宁市第三人民医院检验科,广西南宁 530003

分类号：R722.17

出版年·卷·期（页码）：2012·31·第五期（591-593）

摘要：

目的:探讨血清总胆红素动态变化对新生儿心肌酶改变的影响。方法:选择新生儿黄疸患儿227例,参照新生儿高胆红素血症的诊断标准分为生理性黄疸组(生理组)60例,病理性黄疸组(病理组)167例;病理组根据血清总胆红素(TBIL)浓度不同,分为A(TBIL 230~300 μmol·L^-1)、B(TBIL 301~350 μmol·L^-1)、C(TBIL>351 μmol·L^-1)3个亚组,检测各组天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)含量。结果:病理组中B、C亚组AST、CK、CK-MB水平明显高于生理组,差异有统计学意义(P<0.05或P<0.01);B、C亚组AST、CK-MB、LDH水平高于A亚组,差异有统计学意义(P<0.05或P<0.01)。结论:黄疸能引起心肌酶发生改变,高浓度胆红素可致心肌受损。

Objective: To investigate the influence of serum total bilirubin in dynamic change on the neonate myocardial enzymes. Methods: 227 cases of infant patients with icterus neonatorum were chosen, and were divided into two groups referring to diagnostic standard of newborn hyperbilirubinemia: physiologic jaundice group (physiologic group, 60 cases) and pathologic jaundice group (pathologic group, 167 cases). Cases in the pathologic group were divided into group A(230~300 μmol·L^-1), B(301~350 μmol·L^-1) and C(>350 μmol·L^-1) according to the concentration of serum total bilirubin. Serum AST, LDH, CK, CK-MB in each group were detected. Results: There was a significant difference in comparing the group B, C and physiologic group by AST, CK, CK-MB (P<0.05 or P<0.01). In the pathologic group, AST, CK-MB, LDH in group B and C showed higher than that of group A, there was significantly different(P<0.05 or P<0.01). Conclusion: Icterus could change myocardial enzymes, bilirubin in high concentration might cause cardiac damage.

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