6例人感染新型布尼亚病毒病的临床特征和流行病学调查分析-东南大学学报医学版

6例人感染新型布尼亚病毒病的临床特征和流行病学调查分析

单位：1. 南京医科大学公共卫生学院,江苏南京 210029;
2. 江苏省疾病预防控制中心, 江苏南京 210009;
3. 溧水县疾病预防控制中心,江苏溧水 211200

分类号：R373.3; R181.8

出版年·卷·期（页码）：2012·31·第五期（559-563）

摘要：

目的:分析溧水县2011年确诊的6例人感染新型布尼亚病毒病的临床特征和流行病学特征,为制定预防控制措施提供参考。方法:采用卫生部统一的诊断标准和流行病学个案调查表对病例进行调查。结果:发病率为1.42/10万,死亡率0.24/10万,病死率为16.67%。临床表现主要为发热(6例)、乏力(6例)、食欲减退(6例)、全身酸痛(5例)、腹泻(5例)、恶心(4例);临床实验室检查有血小板计数减少和白细胞计数减少(6例),门冬氨酸氨基转移酶(6例)、磷酸肌酸激酶(6例)、乳酸脱氢酶(6例)、α-羟丁酸脱氢酶(5例)、肌酸激酶同工酶(5例)、胱抑素C(5例)水平升高。病例均来自丘陵村镇,为中老年农民,发病时间集中于4~7月份,部分病例发病前有明确的蜱叮咬史。结论:新型布尼亚病毒感染病例发病初期临床症状不典型,发病有地域特征,高度散发,在丘陵地区生活、生产的居民有较高的感染风险。

Objective: To analyze the clinical and epidemiological characteristics of 6 cases with severe fever with thrombocytopenia syndrome virus(SFTSV) infection of Lishui County in 2011, so as to provide reference for making prevention and control measures. Methods: Investigating cases by uniform diagnostic criteria and epidemiological questionnaire of the ministry of health. Results: The incidence rate of disease was 1.42 per 100 thousand, the mortality rate was 0.24 per 100 thousand. The clinical manifestations including fever (6 cases), fatigue (6 cases), loss of appetite (6 cases), muscular stiffness (5 cases) and diarrhea (5 cases), and nausea (4 cases). Laboratory results including thrombocytopenia and leucopenia (6 cases), elevated AST (6 cases), CPK (6 cases), LDH (6 cases),a-HBDH (5 cases), CK-MB(5 cases) and Cystatin (5 cases). All cases were elderly people from Qiuling Town, and occurred between April to July. There was premorbid history of tick bites in some cases. Conclusions: The clinical symptoms of SFTSV cases were atypical in the early onset. Regional and highly sporadic features were observed. The residents of the hilly area of life, production had a higher risk of infection.

参考文献：

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