>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
基因和基因修饰的骨髓间充质干细胞治疗椎间盘退变的研究进展
作者:谢志阳1  吴小涛2 
单位:1. 东南大学医学院,江苏 南京 210009;
2. 东南大学附属中大医院 骨科,江苏 南京 210009
关键词:椎间盘退变 基因治疗 干细胞治疗 综述 
分类号:R681.5
出版年·卷·期(页码):2012·31·第四期(516-519)
摘要:

骨髓间充质干细胞及相关的基因治疗作为一种新的生物治疗手段,在退变椎间盘修复的领域展现了巨大潜力,作者就其相关进展及问题进行综述。

参考文献:

[1] WADDELL G.Low back pain:a twentieth century health care enigma[J].Spine,1996,21:2820-2825.
[2] DAGENAIS S,CARO J,HALDEMAN S.A systematic review of low back pain cost of illness studies in the United States and internationally[J].Spine J,2008,8(1):8-20.
[3] 郭健行,黄桂成.椎间盘退变影响因素研究进展[J].国际骨科学杂志,2008,29(1):46-48.
[4] URBAN J,SMITH S,FAIRBANKS J C.Nutrition of the interverberal disc[J].Spine,2004,29(23):2700-2709.
[5] 马旭,吕刚,黄涛.软骨终板细胞凋亡及其相关研究进展[J].中国矫形外科杂志,2005,13(13):1021-1023.
[6] WALKER M,ANDERSON D.Molecular basis of intervertebral disc degeneration[J].Spine ,2004,4:158-166.
[7] BERTRAM H,KROEBE R,WANG H,et al.Matrix - assisted cell transfer for intervertebral disc cell therapy[J].Biochem Biophys Res Common,2005,331:1185 -1192.
[8] CTYSTAL R G.Transfer of genes to human early lessons and obstacles to success[J].Science,1995,270(5235):404-410.
[9] S I Y L,ZHAO Y L,HAO H J,et al.MSCs:biological characteristics,clinical applications and their outstanding concerns[J].Ageing Res Rev,2011,1(10):93-103.
[10] YOON S T,PARK J S,KIM K S,et al.ISSLS prize winner:LMP21 up regulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo[J].Spine,2004,29:2603-2611.
[11] WALLACH C J,SOBAJIMA S,WATANABE Y,et al.Gene transfer of the catabolic inhibitor TIMP21 increases measured proteoglycans in cells from degenerated human intervertebral discs[J].Spine,2003,28(20):2331-2337.
[12] LATTERMANN C,OXNER W M,XIAO X,et al.The adeno associated viral vector as a strategy for int radiscal gene transfer in immune competent and pre-exposed rabbits[J].Spine,2005,30:497-504.
[13] STEVEN K,BERNARD P,ROBERT A,et al.Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model[J].Spine J,2012,12(1):7-20.
[14] LIU X,LI K,SONG J,et al.Efficient and stable gene expression in rabbit intervertebral disc cells transduced with a recombinant baculovirus vector[J].Spine,2006,31:732-735.
[15] SUZUKI T ,NISHIDA K,KATUTANI K,et al.Sustained long-term RNA interference in nucleus pulposus cells in vivo mediated by unmodified small interfering RNA[J].Eur Spine J,2009,18(2):263-270.
[16] SEKI S,ASANUMA-ABE Y,MASUDA K,et al.Effect of small interference RNA(siRNA)for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model[J].Arthritis Res Ther,2009,11(6):R166.
[17] 黎叶飞,盛祖龙,姚玉宇,等.两种骨髓间充质干细胞移植途径治疗急性心肌梗死的比较研究[J].东南大学学报:医学版, 2011, 30(5):687-691.
[18] SERIGANOS K,SAKAI D,HIYAMA A,et al.Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model[J].J Orthop Res,2010,28(10):1267-1275.
[19] SOBAJIMA S,VADALA G,SHIMER A,et al.Feasibility of stem cell therapy for intervertebral disc degeneration[J].Spine J,2008,8(6):888-896.
[20] 邱匀峰,吴小涛,赵梓汝,等.骨髓间充质干细胞与髓核共培养的实验研究[J].东南大学学报:医学版,2007,26(4):257-260.
[21] 张福勇,吴小涛,王运涛,等.兔纤维环细胞与骨髓间充质干细胞共培养的初步研究[J].东南大学学报:医学版,2008,27(3):195-198.
[22] LE VISAGE C,KIM S W,TATENO K,et al.Interaction human mesenchymal stem cells with disc cells:changes in extracellular matrix biosynthesis[J].Spine,2006,31(18):2036-2042.
[23] RISBUD M V,ALBERT T J,GUTTAPALLI A,et al.Differentiation of mesenchymal stem cells towards a nucleus pulposus—like phenotype in vitro:implications for cell—based transplantation therapy[J].Spine,2004,29(23):2627-2632.
[24] SAKAI D,MOCHIDA J,IWASHINA T,et al.Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model:potential and limitations for stem cell therapy in disc regeneration[J].Spine,2005,30(21):2379-2387.
[25] LIU H,KEMENY D M,HENG B C,et al.The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells[J].Immunol,2006,176:2864-2871.
[26] LE BLANC K.Immunomodulatory effects of fetal and adult mesenchymal stem cells[J].Cytotherapy,2003,5(6):485-489.
[27] HIYAMA A,MOCHINDA J,IWASHINA T,et al.Transplantation of mesenchymal stem cells in a canine disc degeneration model[J].J Orthopedic Res,2008,26(5):586-600.
[28] REN C,KUMAR S,CHANDA D,et al.The rapeutic potential of mesenchymal stem cells producting interferon-alpha in a mouse melanoma lung metastasis model[J].Stem Cells,2008,26:2332 -2338.
[29] MIYAZAKI M,SUGIYAMA O,TOW B,et al.The effects of lentiviral gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats[J].J Spinal Disord Tech,2008,21(5):372-379.
[30] YANG H L,WU J,LIU J Y,et al.Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-b1 decrease rabbit intervertebral disc degeneration[J].Spine J,2010,10(9):802-810.
[31] SORDI V,MALASIO M,MARCHESI F,et al.Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets[J].Blood,2005,106:419-427.
[32] CHAVAKIS E,URBICH C,DIMMELER S,et al.Homing and engraftment of progenitor cells:a prerequisite for cell therapy[J].J Mol Cellular Cardiol,2008,45(4):514-522.
[33] SON B R,MARQUEZ-CURTIS L A,KUCIA M,et al.Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases[J].Stem Cells,2006,24(5):1254-1264.
[34] 孟晨,吴小涛.SDF1/CXCR4信号轴在调节干细胞迁移及发育中的作用[J].东南大学学报:医学版,2011,30(4):625-629.
[35] 朱洁,周竹娟,龚自力,等.低氧对人骨髓间充质干细胞趋化因子受体CXCR4和CX3CR1表达的影响[J].中国组织工程研究与临床康复,2009,13(23):4485-4489.
[36] BHAKTA S,HONG P,KOC O.The surface adhesion molecule CXCR4 stimulates mesenchymal stem cell migration to stromal cell-derived factor-1 in vitro but does not decrease apoptosis under serum deprivation[J].Cardiovasc Revasc Med,2006,7(1):19-24.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 412684 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364