慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)为一致死及致残性高的疾病,尤其是在急性加重期过后,患者的临床症状虽有所缓解,但其肺功能仍在继续恶化。临床迫切需要寻找特异性和敏感性较高的血清标志物作为COPD的早期诊断、治疗及预后的评估指标。血清KL-6是一种衡量肺泡组织损伤的特异性生物标志物,其是否能作为评价COPD患者的严重程度和预后的一种生化指标有待进一步研究。作者就COPD的炎症机制、肺损伤、氧化应激及与血清KL-6相关性作一简要综述。

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