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椎间盘退变的病理表现及细胞因子调控机制的研究进展
作者:黄勇  吴小涛 
单位:东南大学附属中大医院 骨科,江苏 南京 210009
关键词:椎间盘退变 病理学 细胞因子 信号传导 综述 
分类号:R681.53
出版年·卷·期(页码):2012·31·第四期(492-496)
摘要:

椎间盘退变(intervertebral disk degeneration,IVDD)的主要病理表现为纤维环及髓核细胞变性、坏死,细胞外基质分解,髓核组织由增生的结缔组织取代,纤维环黏液变性、破裂,软骨终板变薄、破裂。在退变椎间盘中,大量炎症因子通过参与炎症反应、诱导基质金属蛋白酶(MMPs)合成并增加其生物活性、诱导细胞凋亡等途径,促进IVDD;另有一群细胞因子可以促进椎间盘细胞合成蛋白多糖、胶原蛋白,抑制细胞凋亡,延缓或改善IVDD。细胞因子的基因表达及合成受到细胞内信号传导通路调控。作者从IVDD的病理表现、IVDD相关细胞因子的特性、调控细胞因子表达的细胞内信号传导通路等方面研究进行了综述。

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