间充质干细胞移植对椎间盘退变修复作用的研究进展-东南大学学报医学版

间充质干细胞移植对椎间盘退变修复作用的研究进展

单位：1. 东南大学医学院, 江苏南京 210009;
2. 东南大学附属中大医院骨科, 江苏南京 210009

分类号：R681.5

出版年·卷·期（页码）：2012·31·第三期（331-333）

摘要：

椎间盘退变的分子生物学基础包括细胞和细胞外基质的退变,通过间充质干细胞(MSCs)移植可发挥其分化潜能、营养效应、细胞增殖及促进细胞外基质增加等效应,从而修复退变的椎间盘。移植的MSCs大部分滞留于移植部位,只有小部分迁移至纤维环外侧,并且需要很长时间。因此,提高移植的MSCs的迁移效率,可能为椎间盘退变的治疗提供新思路。

参考文献：

[1] YOON S,PATEL N.Molecular therapy of the intervertebral disc[J].Spine J,2006,15(3):379-388.
[2] PHILLIPS F M,AN H,KANG J D,et al.Biologic treatment for intervertebral disc degeneration: Summary statement[J].Spine,2003,28(15 Suppl):S99.
[3] 赵梓汝,吴小涛,祁亚斌,等.TGF-β₁干预下体内兔骨髓间充质干细胞对退变椎间盘治疗的实施研究[J].中国矫形外科杂志,2006,14(13):1019-1022.
[4] 张福勇,吴小涛,王运涛,等.兔纤维环细胞和骨髓间充质干细胞共培养的初步研究[J].东南大学学报:医学版,2008,27(3):195-198.
[5] ZHANG Y G,GUO X.Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans[J].Clin Orthop Relat Res,2005(430):219-226.
[6] RICHARDSON S M,HUGHES N,HUNT J A,et al.Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels[J].Biomaterials,2008,29:85-93.
[7] YANG F,LEUNG V,LUK K D K,et,al.Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells[J].Molecular Therapy,2009,17(11):1959-1966.
[8] SAKAI D,MOCHIDA J,YAMAMOTO Y,et al.Transplantation of mesenchymal stem celIs embedded in atelocollagen gel to the intervertebral disc:a potential therapeutic model for disc degeneration[J].Biomaterials,2003,24(20):3531-3541.
[9] 邵建树,吴小涛.兔骨髓间充质干细胞与髓核细胞共培养后的营养效应和类髓核分化效应[J].中国脊柱脊髓杂志,2009,19(5):381-387.
[10] YAMAMOTO Y,MOCHIDA J,SAKAI D,et al.Upregulation of the viability of nucleus pulposus cells by bone marrow-derived stromal cells[J].Spine,2004,29(14):1508-1514.
[11] STRASSBURG S,RICHARDSON S M,FREEMONT A J,et al.Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype[J].Regen Med,2010,5(5):701-11.
[12] ZHANG Y,GUO X,LI T,et al.The effect of injecting bone mesenchymal stem cells into nucleus pulposus on the biochemistry of intervertebral disc[J].Medical Sciences,2007,28(6):675-679.
[13] YANG S H,WU C C,SHIF T T F.In vitro study on interaction between human nucleus pulposus cells and mesenchymal stem cells through paracrine stimulation[J].Spine,2008,33(18):1951-1957.
[14] HENRIKSSON H B,SVANVIK T,JONSSON M,et al.Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model[J].Spine,2009,34(2):141-148.
[15] le VISAGE C,KIM S W,TATENO K,et al.Interaction of human mesenchymal stem cells with disc cells[J].Spine,2006,31(18):2036-2042.
[16] SATOSHI S,ADAM S,JOSEPH K,et al.Feasibility of stem cell therapy for intervertebral disc degeneration[J].Spine,2005,30:2379-2387.
[17] CHRISTINE L,PAULINE B,ANTHONY J F,et al.An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.Arthritis Research & Therapy,2009,11:R20-02-11].http://arthritis-research.com/11/1/R20.
[18] 鲍军平,吴小涛,王运涛,等.干细胞移植延缓椎间盘退变及磁共振示踪研究[J].东南大学学报:医学版,2008,27(3):166-170.
[19] SOBAJIMA S,VADALA G,SHIMER A,et al.Feasibility of a stem cell therapy for intervertebral disc degeneration[J].Spine J,2008,8(6):888-96.

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