慢性心力衰竭患者血浆脑钠肽浓度与体质量指数的相关性-东南大学学报医学版

慢性心力衰竭患者血浆脑钠肽浓度与体质量指数的相关性

单位：1. 江阴市徐霞客医院, 江苏江阴 214407;
2. 江阴市人民医院, 江苏江阴 214407

分类号：R541.6

出版年·卷·期（页码）：2012·31·第二期（199-201）

摘要：

目的:探讨慢性心力衰竭患者脑钠肽(BNP)水平与体质量指数(BMI)的关系,明确BNP水平对慢性肥胖心力衰竭患者预后评估的影响。方法:老年充血性心力衰竭患者54例(男性30例,女性24例,左室射血分数<50%),测量患者身高、体重,根据BMI将患者分为3组:对照组(BMI<24 kg·m^-2)、超重组(BMI＝24~27.9kg·m^-2)及肥胖组(BMI≥28kg·m^-2),通过免疫荧光方法测定患者血浆BNP水平,比较各组血浆BNP水平及BNP水平与BMI的相关性。结果:(1) 肥胖组患者血浆BNP水平明显低于对照组及超重组(均为P<0.01);(2) BNP与BMI之间存在负相关关系(r=-0.91,P<0.01)。结论:心力衰竭患者血浆中BNP浓度随BMI增加而降低,在应用BNP对心力衰竭患者进行心功能评价时,应同时考虑肥胖因素对其产生的影响。

Objective: To explore the relationship between levels of plasma brain natriuretic peptide(BNP) and body mass index(BMI), and to examine the influence of plasma BNP levels on the prognosis value for obesity heart failure patients. Methods: Fifty-four heart failure patients were enrolled in this study(30 males,24 females and LVEF<50%), and heights and weights of each patient were measured and BMl were calculated with these parameter. The patients were divided into 3 groups according to BMI: controll group(BMI<24 kg·m^-2), overweight group (BMI=24-27.9kg·m^-2) and obese group (BMI≥28kg·m^-2). The plasma concentrations of BNP were measured by immunofluorescence method. Results: The concentrations of BNP were significantly lower in obese group compared to normal group and overweight group(P<0.01). BNP levels were inversely correlated with BMI. Conclusion: In heart failure patients, plasma BNP levels are affected by BMI. The influence of BMI must be considered, when assessing the heart function with BNP in heart failure patient.

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