甲型H1N1流感患者外周血淋巴细胞变化-东南大学学报医学版

甲型H1N1流感患者外周血淋巴细胞变化

单位：东南大学附属第二医院, 江苏南京 210003

分类号：R511.7

出版年·卷·期（页码）：2012·31·第二期（146-149）

摘要：

目的:寻求甲型H1N1流感患者外周血淋巴细胞与病情的相关性。方法:比较经实时RT-PCR确诊的183例普通型和64例重症型甲型H1N1流感患者外周血淋巴细胞,分析淋巴细胞计数与疾病分型及病情的相关性。结果:治疗前甲型H1N1流感重症型患者淋巴细胞计数[(1.23±0.76)×10⁹ L^-1]较普通型患者[(1.50±0.59)×10⁹ L^-1]明显偏低(t=2.958,P<0.01);治疗后患者淋巴细胞计数[(1.92±0.79)×10⁹ L^-1]较治疗前[(1.27±0.63)×10⁹ L^-1]明显上升(t=6.33,P<0.01)。结论:淋巴细胞计数对甲型H1N1流感患者临床分型及病情变化有预测作用。

Objective: To explore the relationship between peripheral lymphocyte counts and severity of the disease among H1N1 influenza patients. Methods: Patients infected with the H1N1 virus, including 183 simple and 64 severe cases, were confirmed by real-time reverse-transcriptase-polymerase-chain-reaction assay. Datas of the peripheral lymphocyte counts and clinical features were collected and evaluated. Results: Peripheral lymphocyte counts in severe patients were significantly lower compared with that in simple group [(1.23±0.76)×10⁹ L^-1 vs (1.50±0.59)×10⁹ L^-1, t=2.958,P＜0.01)]. Total lymphocytes counts significantly increased after treatment[(1.92±0.79)×10⁹ L^-1) vs (1.27±0.63)×10⁹ L^-1, t=6.33,P＜0.01)]. Conclusion: Peripheral lymphocyte counts may be associated with the prognosis of the H1N1 influenza.

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