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血浆miRNA检测在肿瘤临床应用的研究进展
作者:石明1  仇雪梅1 2  樊红1 
单位:1. 东南大学 医学院,江苏 南京 210009;
2. 东南大学 生命科学研究院,江苏 南京 210009
关键词:微小RNA 血浆 肿瘤 临床应用 
分类号:R73; R446.4
出版年·卷·期(页码):2012·31·第一期(122-125)
摘要:

微小RNA(micro RNA, miRNA)是一类长度为21~24个核苷酸的非编码小分子RNA,它通过与靶基因3'端非翻译区完全配对及不完全配对地结合来调控基因表达,影响个体发育、细胞增殖等基本生命活动。miRNA调控几乎参与了生物生命活动的各种生物学过程,且与恶性肿瘤的发生、转移及进展相关。在血浆中miRNA具有含量丰富、性质稳定、易于检测等特征,自发现血浆中存在miRNA以来,血浆miRNA作为肿瘤诊断、治疗和预后的潜在生物标志物备受关注。作者对miRNA在肿瘤早期诊断、个体化治疗以及预后监测等方面的应用价值作一综述。

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