Objective: To summarize the clinical experience of coronary artery bypass grafting(CABG) in treatment of coronary artery disease. Methods: The clinical data of 24 patients with coronary atherosclerotic heart disease who underwent CABG were analyzed retrospectively, including operation cases choose, operation method and bypass grafts choose, and preoperative management. Results: Among 24 patients, 14 cases had multiple coronary vessels disease. All cases received CABG through middle stemotony under general anesthesia, with 13 cases of on-pump coronary artery bypass grafting, 11 cases of off-pump coronary artery bypass grafting. The average number of grafts were 2.5(61/24). Cardiac valvular operation were performed in 5 cases. One patient had left ventricular aneurysm resection concomitantly. All patients recovered and were discharged. There was no operative mortality. The follow-up of 2 to 36 months showed that the angina was totally disappeared in all cases. Conclusions: CABG is a safe and effective method for the treatment of coronary artery heart disease. Carrying out the technology in basic-level hospitals should be carefully selected cases. Operation method choose should consider the patient characteristics and medical conditions. Appropriate bypass grafts, well preoperative management is the key of successful operation.