PTTG和bFGF在非小细胞肺癌中的表达及其临床意义-东南大学学报医学版

PTTG和bFGF在非小细胞肺癌中的表达及其临床意义

单位：1. 常州市第二人民医院肿瘤科, 江苏常州 321000;
2. 东南大学附属中大医院肿瘤中心, 江苏南京 210009

分类号：R734.2; Q786

出版年·卷·期（页码）：2009·28·第三期（217-221）

摘要：

目的: 探讨垂体肿瘤转化基因(PTTG)和碱性成纤维细胞生长因子(bFGF)表达水平与非小细胞肺癌(NSCLC)临床及病理学参数之间的关系。方法: 收集手术切除并经病理学确诊的NSCLC及癌周正常肺组织标本,依据实验目的行PTTG和bFGF检测。结果: PTTG和bFGF的表达与NSCLC的临床分期、分化程度有相关性,与年龄、性别、KPS评分、吸烟指数、组织学类型无相关性,并且两者呈正相关性表达。结论: PTTG和bFGF在NSCLC中的高表达,提示了其在NSCLC发生发展中的作用,可为NSCLC的治疗提供可能的靶点。

Objective To study the relationship between the expression of pituitary tumor-transforming gene (PTTG) and basic fibroblast growth factor (bFGF) and clinical and pathological parameter of non small-cell lung cancer.Methods Non small-cell lung cancer and normal lung tissue specimen from operation and pathological diagnosis underwent PTTG or bFGF accordingly.Results The expression of PTTG and bFGF were correlated with TNM stage,histological grades.There was no relationship between the expression of PTTG and bFGF and age,sex,KPS value,smoking index,histological subtype.Conclusion Over-expression of PTTG and bFGF play an important role in the development in non small-cell lung cancer,which may be a new therapeutic target in non small-cell lung cancer.

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