Objective To discuss the application value of different angle angiography digital subtraction(DSA) technique in the interventional management of liver neoplasm.Methods With philips Allrua DSA unit,both conventional and different angle DSA angiography of the proper hepatic artery were performed in 52 patients with liver neoplasm who were divided into control group and different angle DSA group before and after the interventional management.Numbers of lesions and tumor-feeding artery were compared between the images of the two groups.Differential diagnosis signs on small liver cancer and arterioportal shunt by different angle DSA were studied.Results 62 focuses of the liver neoplasm were displayed in control group,the tumor-feeding artery could not be clearly displayed due to excessive tortuosity of the vessels in 18 patients,sub-segmental branches of hepatic artery could not be clearly resolved due to interlay in 21 patients;66 focuses of the liver neoplasm were displayed in different angle DSA group,sub-segmental branches of hepatic artery could be demonstrated satisfactorily in 50 patients.Different angle DSA revealed 4 small lesions,which were missed by conventional angiography.The tumor arteries and lesions were observed and analyzed using χ² test(χ²=12.64,P<0.05).Conclusions The different angle DSA can well display tumor-feeding arteries from different angles and detect small lesions which were overlapped on conventional images.As an important supplementary means,different angle DSA is of great help to improve the successful rate of super-selective catheterization.It is helpful about differential diagnosis between small liver neoplasm and APS.Combined application of different angel DSA with conventional DSA will help to improve transcatheter arterial chemo-embolization efficiency.