经导管肝动脉化学栓塞术联合无水乙醇注射治疗中晚期肝癌的临床观察-东南大学学报医学版

经导管肝动脉化学栓塞术联合无水乙醇注射治疗中晚期肝癌的临床观察

单位：东南大学医学院附属南京第二医院放射科, 江苏南京 210003

分类号：R735.7; R815

出版年·卷·期（页码）：2009·28·第二期（106-109）

摘要：

目的: 比较经导管肝动脉化学栓塞术(TACE)联合经皮无水乙醇注射(PEI)治疗中晚期肝癌与单纯TACE治疗方法的疗效差异。方法: 将60例肝癌患者随机分为两组,A组(31例)予经导管TACE联合PEI治疗,B组(29例)单用TACE治疗,每隔4周重复1次,3次为1个疗程,每次复查AFP、血常规、肝功能与CT,1个疗程后每6个月随访1次,共随访24个月,分析两组1个疗程后的治疗效果、术后不良反应与生存率的差异。结果: 1个疗程后复查结果A组完全缓解(CR)1例、部分缓解(PR)8例、稳定(SD)8例、进展(PD)14例,B组CR 0例、PR 7例、SD 5例、PD 17例;至随访结束A组失访8例,B组失访5例,共失访13例;术后6、12、18、24个月生存率A组依次为80.09%、58.06%、32.25%、22.27%,B组则分别为78.87%、52.39%、44.65%、37.02%;两组术后不良反应无统计学差异。结论: TACE联合PEI治疗中晚期肝癌可提高疗效和晚期生存率。

Objective To assess whether the efficacy of a combination of transcatheter arterial chemoembolization(TACE) and percutaneous ethanol injection (PEI) in the treatment of unresectable hepatocellular carcinoma(HCC) was superior to TACE alone.Methods Sixty patients with HCC were randomly divided into two groups.Group A included 31 patients,which were treated by TACE and PEI.Group B included 29 patients,which were treated with TACE alone.Effect,side effect and survival rate of all patients were analyzed after treatment by follow-up survey,CT and their blood laboratory examination.Results There were CR 1 case,PR 8 cases,SD 8 cases,PD 14 cases in group A,while CR 0 case,PR 7 cases,SD 5 cases,PD 17 cases in group B.The patients survival rates of group A were 80.09%,58.06%,32.25%,22.27%,while group B were 78.87%,52.39%,44.65%,37.02% in 6,12,18 and 24 months follow-up survey respectively.The side effects had no differences between two groups.Conclusion The combination of TACE and PEI is superior to TACE alone in efficacy and survival rate of patients.

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