老年人执行计算任务的fMRI研究-东南大学学报医学版

老年人执行计算任务的fMRI研究

单位：东南大学附属中大医院放射科, 江苏南京 210009

分类号：R445.2; R338.2

出版年·卷·期（页码）：2009·28·第一期（26-29）

摘要：

目的: 用功能磁共振成像(fMRI)探讨老年人减法计算时脑的活动情况。方法: 对20例老年健康受试者进行简单及复杂计算任务时的fMRI扫描,采用SPM2软件进行数据分析和脑功能区定位。结果: 简单及复杂计算主要涉及的神经网络为额前区、顶叶、扣带回、小脑及枕叶,复杂计算时涉及的部位更多,且以左侧半球为主。结论: 额前区、顶叶和扣带回的后方是老年人执行计算任务的主要部位,复杂计算时,需要更多的脑功能区参与;左侧半球为老年人计算任务时的优势半球。

Objective To explore the activation patterns of brain in calculation with functional MRI in elderlies.Methods Functional MR images were acquired in 20 healthy old subjects when they were receiving simple calculation and complex calculation experiment.SPM2 was used to process data and localize functional areas of brain.Results Prefrontal cortex,parietal lobe,cingulate gyrus,cerebellum and occipital lobe were activated during simple calculation and complex calculation task.The activated area was larger in complex calculation task than that in simple one andleft hemisphere was the dominating area.Conclusion Prefrontal cortex,parietal lobe posterior cingulate gyrus are main network in calculation task of old subjects.With the increase of difficulty,more functional region should be involved.Left hemisphere was the dominating one in calculation task of old subjects.

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