[Abstract] Objective: To explore risk factors of prognosis on advanced gastric cancer(AGC) patients after surgical radical resection and study its impact on patients long-term prognosis. Methods: Clinical data were analyzed from 675 patients who underwent surgical radical resection for advanced gastric cancer(AGC).Potential clinicopathological prognostic factors were examined by Kaplan-Meier univariate and Cox proportional hazards model regression multivariate analysis. Results The 1,3 and 5 years cumulative recurrence rate was 27.7%、67.9% and 84.4% respectively(median recurrence time，31.7 months). Which accounted for 29.1% of local recurrence，52.6% of peritoneal recurrence and 18.3% of blood-borne recurrence.The 1,3 and 5 years overall survival rate was 88.2%、54.5% and 36.7% respectively.Univariate analysis revealed tumor Borrmann type, depth of invasion, lymph node metastasis, histological type, TNM stage,surgical margin and adjuvant chemotherapy as significant factors influencing patients prognosis(P＜0.05).Multivariate analysis revealed histological type，TNM stage and surgical margin were significant independent predictors of poor prognosis. Conclusion Histological type，TNM stage and surgical margin were the most important prognostic factors for advanced gastric carcinoma after surgical radical resection.United D2 radical resection of advanced gastric cancer and adjuvant chemotherapy may further improve the prognosis.