Objective: To study the impact of cognitive emotion regulation strategy on the first three factors of SCL-90 medical students scored. Methods: 586 Medical students were asked to complete Cognitive Emotion Regulation Questionaire-Chinese Version and Symptom Checklist 90. Results: ①The first three factors of SCL-90 medical students scored are obsessive-compulsive, interpersonal sensitivity, depression in sequence; ②The combination of Catastrophizing, Rumination and Self blame can predict 12.1% of the variation of obsessive- compulsive, The combination of Catastrophizing, Self blame, blaming others and Rumination can predict 15.9% of the variation of interpersonal sensitivity, Catastrophizing and Self blame can explain 12.9% extent of variations of depression. Conclusion: Catastrophizing and Self blame are common predictors of obsessive-compulsive, interpersonal sensitivity and depression, Rumination can predict obsessive- compulsive and interpersonal sensitivity to a certain degree, and blaming others has some contribution to interpersonal sensitivity.