Objective To evaluate the application of Fast-track Surgery for the perioperative management of colonic cancer resection. Method From October 2010 to May 2010, 47 patients treated with fast-track surgery were analyzed retrospectively, who were compared with 80 patients treated with traditional method. Postoperative recovery index and completion rate of FT items were studied and compared. Result In early rehabilitation, first flastus of patients in FT Group was significantly earlier than that in Traditional Group (P<0.05). Postoperative hospital stay was also shorter in FT group(P<0.05). For completion of FT items, all patients in FT Group received restrict rehydration while no patient in Traditional Group did. The completion rates were of early oral intake and no routine use of drain significant higher(P<0.05) in FT Group. However, there were no significant differences in completion rates of early ambulationg, early removal of nasogastric tube and urinary catheter between the two groups. For the complications, there were also no significant differences between the two groups. Conclusion Fast-track surgery for the perioperative management of colonic cancer could accelerate return of bowel movement and shorten postoperative hospital stay. Better urbanization is need to make a better application of fast-track surgery.