血清载脂蛋白B、载脂蛋白B/载脂蛋白A1值与冠状动脉病变的相关性分析-东南大学学报医学版

血清载脂蛋白B、载脂蛋白B/载脂蛋白A1值与冠状动脉病变的相关性分析

单位：安徽省蚌埠市第三人民医院

分类号：

出版年·卷·期（页码）：2011·30·第四期（577-580）

摘要：

目的研究分析血清载脂蛋白B、载脂蛋白B/A1比值与冠状动脉粥样病变及其严重程度的关系。方法比较血清ApoB、ApoB/A1比值在冠心病及对照组中的变化，分析ApoB、ApoB/A1比值与颈动脉内中膜厚度（IMT）、冠状动脉病变支数及狭窄严重程度的相关性。结果冠心病组（CHD）血清ApoB（1.02±0.25 Vs 0.86±0.22 g/L, p<0.05）, ApoB/A1比值（0.94±0.50Vs 0.78±0.23 ,p<0.05）显著高于对照组；相关分析显示：ApoB、ApoB/A1比值与IMT、冠状动脉病变支数及狭窄程度呈显著性正相关。结论 ApoB、ApoB/A1比值与冠心病发病学密切相关，反映了动脉粥样硬化的程度，与冠状动脉病变的程度密切相关。

Objective: To investigate the correlation of Serum Apolipoprotion B(ApoB) levels and Apolipoprotion B/ Apolipoprotion A-1 ratio with coronary heart disease(CHD). Methods: The changes of serum ApoB and ApoA1 levels were investigated between CHD and controll group. Correlation and regression analysis were applied to find the correlation between serum ApoB levels ,ApoB/A1 ratio and the carotid IMT ,the narrowing vessel number and narrowing degree in CHD. Result : ApoB（1.02±0.25 Vs 0.86±0.22 g/L,p<0.05）ApoB/A1 ratio（0.94±0.50Vs 0.78±0.23 ,p<0.05）were significantly higher in CHD group than controll group , ApoA1 changes inversely ;Correlation analysis shows that ApoB, ApoB/A1 ratio were positively correlated to the carotid IMT ,the narrowing vessel number and the narrowing degree in CHD. The positive correlation was found with ApoA1.Conclutions: The Serum ApoB levels, ApoB/A1 ratio are significantly correlative with CHD, Maybe reflect the severity of CHD.

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