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CT检查联合VEGF-C表达检测在非小细胞肺癌淋巴结转移诊断中的价值
作者:张欣贺 施雪峰  
单位:辽宁医学院研究生院
关键词:非小细胞肺癌 体层摄影术 X线计算机 VEGF-C 淋巴结转移 
分类号:
出版年·卷·期(页码):2011·30·第三期(460-463)
摘要:

[摘要] 目的:用CT检查联合VEGF-C表达检测的方法以提高非小细胞肺癌淋巴结转移的诊断水平。方法:对46例非小细胞肺癌患者行CT检查和术后肺癌标本免疫组化检查,分别判断纵隔淋巴结转移情况,以术后淋巴结病理结果为标准,分析两种方法及两种方法联合应用对纵隔淋巴结转移的诊断价值。结果:CT检查对纵隔淋巴结转移的敏感性为65.00﹪,特异性为80.77﹪,符合率为73.91﹪。VEGF-C阳性表达对纵隔淋巴结转移的敏感性为90.00﹪,特异性为65.38﹪,符合率为76.09﹪。两种方法联合对纵隔淋巴结转移诊断的敏感性为95.00﹪,特异性为88.46﹪,准确率为91.30﹪。结论:CT检查联合VEGF-C表达检测能提高非小细胞肺癌纵隔淋巴结转移的诊断符合率, 利于肺癌分期、评估预后和制定治疗措施。

[Abstract] Objective: CT examination combined with the expression of VEGF-C detection methods to improve non-small cell lung cancer diagnosis level. Methods: 46 patients with non-small cell lung cancer were examinatted to determine mediastinal lymph node metastasis by CT and immunohistochemical examination, after the examination we analysis the diagnositic significance of mediastinal lymph node metastasis by two methods and combined use of two methods, and lymph node pathology results are as the standard.Results: sensitivity of CT examination to mediastinal lymph node metastasis was 65.00﹪, and specificity is 80.77﹪, the rate is 73.91﹪. The positive expression of VEGF-C sensitivity of mediastinal lymph node metastasis was 90.00﹪, specificity is 65.38﹪, the rate is 76.09﹪. sensitivity of Combined two methods of mediastinal lymph node metastases is 95.00﹪, specificity is 88.46﹪, rate is 91.30﹪.Conclusion: CT examination combined expression of VEGF-C can improve the detection of non-small cell lung cancer mediastinal lymph node metastasis diagnosis rate, conducive to lung cancer staging, assessment of prognosis and the development of therapeutic measures.

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