P2Y12基因多态性与PCI术后患者氯吡格雷反应变异性的关联分析-东南大学学报医学版

P2Y12基因多态性与PCI术后患者氯吡格雷反应变异性的关联分析

单位：中国药科大学

分类号：

出版年·卷·期（页码）：2011·30·第三期（449-453）

摘要：

目的: 探讨P2Y12受体G52T基因多态性与PCI术后患者氯吡格雷反应变异性的关系。方法: 提取 109例PCI术后患者外周血基因组DNA，采用DNA测序技术检测P2Y12受体G52T基因多态性。以5 μ和20 μmol•L-1 ADP为诱导剂，测定患者服用氯吡格雷前及服药后12h、36h血小板聚集率。结果：109例PCI术后患者中GG基因型、GT基因型和TT基因型分别占79.82%、17.42%和2.76%。两组患者（GG纯合子组和T基因携带组）在服用氯吡格雷前后不同时间点的最大血小板聚集率无显著差异。结论: P2Y12受体G52T基因多态性可能与PCI术后患者氯吡格雷反应变异性没有关联。

To explore the association of P2Y12 gene polymorphisms with cliopidogrel response variability in Chinese patients undergoing PCI. M ethods　 Genomic DNA was extracted from the leukocyte cell of each blood samples both in 109 patients undergoing PCI. DNA sequencing analysis were employed to assess the polymorphism of P2Y12 gene G52T. Platelet aggregation (5 and 20 μmol•L-1 ADP) were measured at baseline, 12 hours, 36 hours after the clopidogrel loading dose. Results　The GG genotype, GT genotype, TT genotype was 79.82%,17.42%and2.76%, respectively. There was no significant difference in platelet aggregation at different time points between two different P2Y12 genotypes (GG homozygote and T aelle carrier). Conclusion　The P2Y12 G52T polymorphisms may not associate with the clopidogrel response variability in Chinese patients undergoing PCI.

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