不同表面修饰的Fe3O4纳米颗粒在体肿瘤成像研究-东南大学学报医学版

不同表面修饰的Fe3O4纳米颗粒在体肿瘤成像研究

单位：中国科学院化学研究所

分类号：

出版年·卷·期（页码）：2011·30·第一期（63-66）

摘要：

摘要：目的：比较两种不同表面修饰的Fe3O4纳米颗粒作为肿瘤探针时进行在体MRI成像的区别。方法：采用两种不同表面修饰的Fe3O4作为磁共振造影剂，并利用其表面羧基与具有靶向识别肿瘤表面整合素受体（Integrin αvβ3）的c(RGDyK)多肽进行耦联，制备出具有肿瘤靶向性的磁共振分子探针。以荷人脑胶质瘤（U-87 MG）裸鼠为动物模型，进行体内MRI成像。结果：两种纳米颗粒均能够产生明显的T2造影效果，然而由于其表面电性的不同，导致两种纳米颗粒在成像时达到最佳成像效果的时间有所不同。

Abstract: Objective: To compare the contrast effect for MR imaging of tumor by using two types of Fe3O4 nanoparticles bearing with different surface ligands as tumor-targeting contrast agent. Method: The tumor-targeting peptide c(RGDyK) was conjugated with Fe3O4 nanoparticles bearing with carboxylic groups by the conjugation reaction mediated by EDC and sulfo-NHS. Then, the conjugates were applied to in vivo detecting tumors in BALB/c nude mice bearing U-87 MG human glioma cancer xenografts. Conclusion: The two different types of Fe3O4 nanoparticles both can obtain obvious contrast effect, however, the best contrast images has to be acquired at different time, which may be affected by the different surface charge of the Fe3O4 nanoparticles.

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