Objective To observe the effect and toxicity in advanced non-small cell lung cancer(NSCLC) after intravenous drip low-dose paclitaxel (PTX)plus cisplatin(DDP).Methods 32 NSCLC patients were testified by pathologic or cytologic diagnosis,were received low-dose paclitaxel 25 mg/m2/d by continuous intravenous drip 16 hours, on d1-3、8-10,and cisplatin 75 mg/m2 by intravenous infusion on d1-3、d8～10.The treatment was repeated every 21 days, up to 2 cycles. Therapeutic effect and side2 effects were observed . Results　I n 32 patients, the overall response rate was 43.8%. Response rates of initial treat ment and retreat ment were 50.0% (9 /18) and 35.7% ( 5 /14) respectively . No significant difference was seen between t wo groups (χ2= 0.6429, P＞0.05) . The main toxicities were hypoplasia of bonemarrow,alopecie and hypodynamia, and other side effects were mild. all of these can be tolerated by patients. Conclusion:　The combination therapy of low-dose paclitaxel plus cisplatin could be the ideal chemotherapy protocol with tolerable toxicity for patients advanced NSCLC.