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绿色荧光蛋白细胞毒性研究进展
作者:李颖1  纪木火2  杨建军2 
单位:1. 江阴市人民医院, 江苏 江阴 214400;
2. 郑州大学附属第一医院 麻醉科, 河南 郑州 450052
关键词:绿色荧光蛋白 细胞毒性 综述 
分类号:Q816
出版年·卷·期(页码):2020·39·第一期(116-119)
摘要:

绿色荧光蛋白(GFP)是重要的探针分子,已广泛应用于标记特定分子或细胞、追踪及测量特定目的基因表达,在基因治疗领域应用前景广阔。然而,有研究发现GFP能导致细胞形态、代谢、生理功能异常,甚至引发细胞病理性改变乃至死亡。本文中作者综述了GFP在在体、体外研究中毒副作用的证据,探讨其可能毒性机制,为GFP相关实验结果解读提供参考。

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