支气管哮喘（简称哮喘）是一种以气道炎症、气道高反应性和气道重塑为特征的慢性呼吸系统疾病，近十余年来其发病率呈现持续上升趋势。随着对哮喘发病机制研究的不断深入，发现白细胞介素13（IL-13）在哮喘的发病机制中起到中轴的作用。有研究表明，硫酸酯酶修饰因子（SUMF）不仅可以与IL-13相结合，且可以抑制IL-13的分泌，推测SUMF在哮喘的发病机制中起到重要作用，这可能为哮喘的防治提供新的线索。作者就SUMF在哮喘发病机制中作用的研究进展作一综述。

[1] HAMID Q,TULIC M.Immunobiology of asthma[J].Annu Rev Physiol,2009,71:489-507.
[2] TREVOR J L,DESHANE J S.Refractory asthma:mechanisms,targets,and therapy[J].Allergy,2014,69(7):817-827.
[3] 帅勇,胡兴旺,易朵,等.重叠延伸PCR法构建小鼠Sumf1基因的定点突变真核表达载体[J].生命科学研究,2009,13(5):430-436.
[4] SARDIELLO M,ANNUNZIATA I,ROMA G,et al.Sulfatases and sulfatase modifying factors:an exclusive and promiscuous relationship[J].Hum Mol Genet,2005,14(21):3203-3217.
[5] COSMA M P,PEPE S,ANNUNZIATA I,et al.The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases[J].Cell,2003,113(4):445-456.
[6] 刘蕾,梁红艳,姜晓峰.SUMF1及SUMF2对硫酸酯酶功能的影响[J].医学综述,2015,21(14):2522-2524.
[7] FRALDI A,BIFFI A,LOMBARDI A,et al.SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies[J].Biochem J,2007,403(2):305-312.
[8] COSMA M P,PEPE S,ANNUNZIATA I,et al.The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases[J].Cell,2003,113(4):445-456.
[9] JASZCZUK I,SCHLOTAWA L,DIERKS T,et al.Expanding the genetic cause of multiple sulfatase deficiency:A novel SUMF1 variant in a patient displaying a severe late infantile form of the disease[J].Mol Genet Metab,2017,121(3):252-258.
[10] COSMA M P,PEPE S,ANNUNZIATA I,et al.The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases[J].Cell,2003,113(4):445-456.
[11] 杨春,张婉莹,梁红艳,等.pEGFP-C3/SUMF2重组真核表达载体的构建及在人支气管上皮细胞中的表达[J].中华临床免疫和变态反应杂志,2012,6(3):168-172.
[12] BAENZIGER J U.A major step on the road to understanding a unique posttranslational modification and its role in a genetic disease[J].Cell,2003,113(4):421-422.
[13] GANDE S L,MARIAPPAN M,SCHMIDT B,et al.Paralog of the formylglycine-generating enzyme-retention in the endoplasmic reticulum by canonical and noncanonical signals[J].FEBS J,2008,275(6):1118-1130.
[14] LIANG H,LI Z,XUE L,et al.SUMF2 interacts with interleukin-13 and inhibits interleukin-13 secretion in bronchial smooth muscle cells[J].J Cell Biochem,2009,108(5):1076-1083.
[15] BERGER K I,FAGONDES S C,GIUGLIANI R,et al.Respiratory and sleep disorders in mucopolysaccharidosis[J].J Inherit Metab Dis,2013,36(2):201-210.
[16] SCHLOTAWA L,ENNEMANN E C,RADHAKRISHNAN K,et al.SUMF1 mutations affecting stability and activity of formylglycine generating enzyme predict clinical outcome in multiple sulfatase deficiency[J].Eur J Hum Genet,2011,19(3):253-261.
[17] DIEZ-ROUX G,BALLABIO A.Sulfatases and human disease[J].Annu Rev Genomics Hum Genet,2005,6:355-379.
[18] ARTEAGA-SOLIS E,SETTEMBRE C,BALLABIO A,et al.Sulfatases are determinants of alveolar formation[J].Matrix Biol,2012,31(4):253-260.
[19] SETTEMBRE C,ANNUNZIATA I,SPAMPANATO C,et al.Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency[J].Proc Natl Acad Sci U S A,2007,104(11):4506-4511.
[20] WEIDNER J,JARENBACK L,DE JONG K,et al.Sulfatase modifying factor 1(SUMF1) is associated with chronic obstructive pulmonary disease[J].Respir Res,2017,18(1):77.
[21] BUONO M,COSMA M P.Sulfatase activities towards the regulation of cell metabolism and signaling in mammals[J].Cell Mol Life Sci,2010,67(5):769-780.
[22] ZITO E,FRALDI A,PEPE S,et al.Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2[J].EMBO Rep,2005,6(7):655-660.
[23] ZITO E,BUONO M,PEPE S,et al.Sulfatase modifying factor 1 trafficking through the cells:from endoplasmic reticulum to the endoplasmic reticulum[J].EMBO J,2016,35(23):2614-2615.
[24] MARIAPPAN M,PREUSSER-KUNZE A,BALLEININGER M,et al.Expression,localization,structural,and functional characterization of pFGE,the paralog of the Calpha-formylglycine-generating enzyme[J].J Biol Chem,2005,280(15):15173-15179.
[25] ZHU J,YAMANE H,COTE-SIERRA J,et al.GATA-3 promotes Th2 responses through three different mechanisms:induction of Th2 cytokine production,selective growth of Th2 cells and inhibition of Th1 cell-specific factors[J].Cell Res,2006,16(1):3-10.
[26] ZHANG W Y,LIANG H Y,YANG C,et al.Sos recruitment system for the analysis of the interaction between sulfatase-modifying factor 2 subtypes and interleukin-13[J].Genet Mol Res,2013,12(4):5664-5672.
[27] 张录,梁红艳,张婉莹,等.pPET-SUMF2各亚型的原核质粒构建及蛋白表达[J].中国科技论文,2014,9(9):1036-1038.
[28] FANG C,LI X,LIANG H,et al.Downregulation of SUMF2 gene in ovalbumin-induced rat model of allergic inflammation[J].Int J Clin Exp Pathol,2015,8(10):12053-12063.
[29] CHAPMANA A M,MALKIN D J,CAMACHO J,et al.IL-13 overexpression in mouse lungs triggers systemic genotoxicity in peripheral blood[J].Mutat Res,2014,769:100-107.
[30] SATO T,NAMBA Y,KASHIHARA Y,et al.Clinical significance of platelet reactivity during prasugrel therapy in patients with acute myocardial infarction[J].J Cardiol,2017,70(1):35-40.