组蛋白修饰是表观遗传学的重要形式，参与各种生命活动及疾病的形成。近年来，随着对组蛋白甲基化修饰及其在胃癌发生发展中作用研究成果的不断涌出，揭示了胃癌中这一修饰的变化规律及其作用机制。作者就胃癌中常见的组蛋白赖氨酸甲基化修饰形式、表达模式、基因表达调控及其在胃癌诊断与预后判定中的作用等方面作一综述，以期为胃癌的临床诊治提供新的靶点。

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