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组蛋白赖氨酸甲基化修饰与胃癌发病机制相关性的研究进展
作者:孙瑞  樊红 
单位:东南大学 医学院, 江苏 南京 210009
关键词:表观遗传调控 组蛋白修饰 组蛋白赖氨酸甲基化 胃癌 文献综述 
分类号:R735.2
出版年·卷·期(页码):2019·38·第三期(536-540)
摘要:

组蛋白修饰是表观遗传学的重要形式,参与各种生命活动及疾病的形成。近年来,随着对组蛋白甲基化修饰及其在胃癌发生发展中作用研究成果的不断涌出,揭示了胃癌中这一修饰的变化规律及其作用机制。作者就胃癌中常见的组蛋白赖氨酸甲基化修饰形式、表达模式、基因表达调控及其在胃癌诊断与预后判定中的作用等方面作一综述,以期为胃癌的临床诊治提供新的靶点。

参考文献:

[1] FERLAY J,COLOMBET M,SOERJOMATARAM I,et al.Cancer incidence and mortality patterns in Europe:estimates for 40 countries and 25 major cancers in 2018[J].Eur J Cancer,2018,103:356-387.
[2] VAN CUTSEM E,SAGAERT X,TOPAL B,et al.Gastric cancer[J].Lancet,2016,388(10060):2654-2664.
[3] 孙燕,姜藻.胃癌分子靶向治疗的现状及研究进展[J].东南大学学报(医学版),2013,32(2):235-238.
[4] 时越.雷莫芦单抗治疗晚期胃癌的研究现状[J].现代医学,2017,45(2):314-316.
[5] PERRI F,LONGO F,GIULIANO M,et al.Epigenetic control of gene expression:potential implications for cancer treatment[J].Crit Rev Oncol Hematol,2017,111:166-172.
[6] YANG W,GU J,ZHEN T.Recent advances of histone modification in gastric cancer[J].J Cancer Res Ther,2014,10(Suppl):240-245.
[7] KORNBERG R D.Chromatin structure-repeating unit of histones and DNA[J].Science,1974,184(4139):868-871.
[8] MILLER K I,VANHOLDE K E,TOUMADJE A,et al.Structure and function of the carboxyl-terminal oxygen-binding domain from the subunit of Octopus dofleini hemocyanin[J].Biochemistry,1988,27(19):7282-7288.
[9] ZHANG T,COOPER S,BROCKDORFF N.The interplay of histone modifications-writers that read[J].Embo Rep,2015,16(11):1467-1481.
[10] HERZ H,GARRUSS A,SHILATIFARD A. SET for life biochemical activities and biological functions of SET domain-containing proteins[J].Trends Biochem Sci,2013,38(12):621-639.
[11] KOOISTRA S M,HELIN K. Molecular mechanisms and potential functions of histone demethylases[J].Nat Rev Mol Cell Bio,2012,13(5):297-311.
[12] BARSKI A,CUDDAPAH S,CUI K,et al.High-resolution profiling of histone methylations in the human genome[J].Cell,2007,129(4):823-837.
[13] RAO R C,DOU Y.Hijacked in cancer:the KMT2(MLL) family of methyltransferases[J].Nat Rev Cancer,2015,15(6):334-346.
[14] YANG Z,AUGUSTIN J,CHANG C,et al.The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells[J].Blood,2014,124(13):2025-2033.
[15] LEE Y J,HAN M E,BAEK S J,et al.Roles of DPY30 in the proliferation and motility of gastric cancer cells[J].PLoS One,2015,10(7):e131863.
[16] TORRES I O,KUCHENBECKER K M,NNADI C I,et al.Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism[J].Nat Commun,2015,6:6204.
[17] VARALJAI R,ISLAM A B M M,BESHIRI M L,et al.Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells[J].Gene Dev,2015,29(17):1817-1834.
[18] NISHIBUCHI G,SHIBATA Y,HAYAKAWA T,et al.Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase(NuRD) complex[J].J Biol Chem, 2014,289(42):28956-28970.
[19] GALE M,SAYEGH J,CAO J,et al.Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance[J].Oncotarget,2016,7(26):39931-39944.
[20] YAN X,ZHANG C,LIU S,et al.Two-carrier transport in SrMnBi2 thin films[J].Front Phys,2017,12(3):127209.
[21] MCDANIEL S L,STRAHL B D.Shaping the cellular landscape with Set2/SETD2 methylation[J].Cell Mol Life Sci,2017,74(18):3317-3334.
[22] HUANG K K,MCPHERSON J R,TAY S T,et al.SETD2 histone modifier loss in aggressive GI stromal tumours[J].Gut,2016,65(12):1960-1972.
[23] ZHAO J X,LI X W,SHI B Y,et al. Effect of histone modifications on hMLH1 alternative splicing in gastric cancer[J].Tumour Biol,2017,39(4):1010428317697546.
[24] KANG J Y,KIM J Y,KIM K B,et al.KDM2B is a histone H3K79 demethylase and induces transcriptional repression via sirtuin-1-mediated chromatin silencing[J].FASEB J,2018,32(10):5737-5750.
[25] DONNER I,KIVILUOTO T,RISTIMAKI A,et al.Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer[J].Fam Cancer,2015,14(2):241-246.
[26] MUTLU B,CHEN H,MORESCO J J,et al.Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C.elegans embryos[J].Sci Adv,2018,4(8):eaat6224.
[27] KENIRY A,GEARING L J,JANSZ N,et al.Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing[J].Epigenet Chromatin,2016,9:16.
[28] HE Y,ZHAO Y,WANG L,et al.LSD1 promotes S-phase entry and tumorigenesis via chromatin co-occupation with E2F1 and selective H3K9 demethylation[J].Oncogene,2018,37(4):534-543.
[29] ROWBOTHAM S P,LI F,DOST A F M,et al.H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression[J].Nat Commun,2018,9(1):4559.
[30] SHUAI W,WU J,CHEN S,et al.SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter[J].Cancer Lett,2018,422:56-69.
[31] LI Q,WANG X,LU Z,et al.Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus[J].PLoS One,2010,5(10):e13732.
[32] NISHIKAWAJI T,AKIYAMA Y,SHIMADA S,et al.Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer[J].Oncotarget,2016,7(41):67251-67265.
[33] HAN F,REN J,ZHANG J,et al.JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression[J].Oncotarget,2016,7(25):38626-38637.
[34] LAN F,BAYLISS P E,RINN J L,et al.A histone H3 lysine 27 demethylase regulates animal posterior development[J].Nature,2007,449(7163):683-689.
[35] SIMON J A,LANGE C A.Roles of the EZH2 histone methyltransferase in cancer epigenetics[J].Mutat Res,2008,647(1-2):21-29.
[36] BAI J,CHANG W,CAI M,et al.Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus[J].Int J Biochem Cell Biol,2015,65:104-112.
[37] LEE Y,CHANG W,CHEN Y,et al.Hsp90 alpha mediates BMI1 expression in breast cancer stem/progenitor cells through facilitating nuclear translocation of c-Myc and EZH2[J].Int J Mol Sci,2017,18(9):1986.
[38] YU J,YU J,MANI R,et al.An integrated network of androgen receptor,polycomb,and TMPRSS2-ERG gene fusions in prostate cancer progression[J].Cancer Cell,2010,17(5):443-454.
[39] HE L,CAI M,XU G,et al.Prognostic significance of overexpression of EZH2 and H3k27me3 proteins in gastric cancer[J].Asian Pac J Cancer Prev,2012,13(7):3173-3178.
[40] WANG M,GUO C,WANG L,et al.Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription[J].Cell Death Dis,2018,9(2):238.
[41] CHOI J H,SONG Y S,YOON J S,et al.Enhancer of zeste homolog 2 expression is associated with tumor cell proliferation and metastasis in gastric cancer[J].APMIS,2010,118(3):196-202.
[42] QI Y,ZHANG X,KANG Y,et al.Genome-wide transcriptional profiling analysis reveals annexin A6 as a novel EZH2 target gene involving gastric cellular proliferation[J].Mol Biosyst,2015,11(7):1980-1986.
[43] NELSON D M,JABER-HIJAZI F,COLE J J,et al.Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability[J].Genome Biol,2016,17(1):158.
[44] FRAGA M F,BALLESTAR E,VILLAR-GAREA A,et al.Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer[J].Nat Genet,2005,37(4):391-400.
[45] KHAN S A,AMNEKAR R,KHADE B,et al.p38-MAPK/MSK1-mediated overexpression of histone H3 serine 10 phosphorylation defines distance-dependent prognostic value of negative resection margin in gastric cancer[J].Clin Epigenetics,2016,8:88.

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