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SIRT2在神经系统疾病中作用的研究进展
作者:翟江燕1 2  沈涛1 
单位:1. 昆明理工大学 医学院, 云南 昆明 650594;
2. 云南省第一人民医院, 云南省临床基础医学研究所, 云南省出生缺陷与遗传病研究重点实验室, 云南 昆明 650032
关键词:沉默信息调节因子2 神经系统疾病 脂质代谢 文献综述 
分类号:R741.02
出版年·卷·期(页码):2019·38·第三期(517-521)
摘要:

沉默信息调节因子2(SIRT2)在生命活动过程中具有非常重要的意义,参与了包括细胞周期、细胞存活、能量代谢、神经炎症、肿瘤发生、脂肪细胞分化、脂肪酸的氧化和能量消耗等过程的调控。作者主要针对SIRT2与神经系统疾病之间的关系进行综述,并进一步阐述SIRT2在神经系统炎症、脂质代谢等方面的作用机制。

参考文献:

[1] BLANDER G,GUARENTE L.The Sir2 family of protein deacetylases[J].Annu Rev Biochem,2004,73:417-435.
[2] MA Q,WOOD T K.Protein acetylation in prokaryotes increases stress resistance[J].Biochem Biophys Res Commun,2011,410:846-851.
[3] 戚欣欣,孙莉.Sirtuin家族及其生物学特性[J].华夏医学,2016,29(1):169-174.
[4] NIE H,LI Y,WANG C,et al.SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia[J].Int J Physiol Pathophysiol Pharmacol,2014,6(3):166-171.
[5] IMAI S,GUARENTE L.NAD+ and sirtuins in aging and disease[J].Trends Cell Biol,2014,24(8):464-471.
[6] YUAN Q,ZHAN L,ZHOU Q Y,et al.SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy[J].Eur J Pharmacol,2015,764:554-561.
[7] 彭亚军,胡高云,李乾斌.去乙酰化酶SIRT2及其抑制剂的研究进展[J].中国药物化学杂志,2017,27(4):315-324.
[8] WANG F,TONG Q.SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma[J].Mol Biol Cell,2009,20(3):801-808.
[9] CIARLO E,HEINONEN T,THEROUDE C,et al.Sirtuin 2 deficiency increases bacterial phagocytosis by macrophages and protects from chronic staphylococcal infection[J].Front Immunol,2017,8:1037.
[10] WANG B,ZHANG Y,CAO W,et al.SIRT2 plays significant roles in Lipopolysaccharides-induced neuroinflammation and brain injury in mice[J].Neurochem Res,2016,41(9):2490-2500.
[11] BOCHE D,PERRY V H,NICOLL J A.Review:activation patterns of microglia and their identification in the human brain[J].Neuropathol Appl Neurobiol,2013,39(1):3-18.
[12] LIU T,ZHANG T,YU H,et al.Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption[J].J Neuroinflammation,2014,11:107.
[13] HAN Z,SHEN F,HE Y,et al.Activation of alpha-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress[J].PLoS One,2014,9(8):e105711.
[14] CHEN H,WU D,DING X,et al.SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia[J].Neuroreport,2015,26(2):88-93.
[15] LI W,CHEN Z,YAN M,et al.The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation[J].J Neurochem,2016,136(3):651-659.
[16] MICHELUCCI A,BITHELL A,BURNEY M J,et al.The neurogenic potential of astrocytes is regulated by inflammatory signals[J].Mol Neurobiol,2016,53(6):3724-3739.
[17] BUCKLEY S M,DELHOVE J M,PEROCHEAU D P,et al.In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters[J].Sci Rep,2015,5:11842.
[18] PAIS T F,SZEGO E M,MARQUES O,et al.The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation[J].Embo J,2013,32(19):2603-2616.
[19] CHEN X,WALES P,QUINTI L,et al.The sirtuin-2 inhibitor AK7 is neuroprotective in models of parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia[J].PLoS One,2015,10(1):e0116919.
[20] LIU R,DANG W,DU Y,et al.SIRT2 is involved in the modulation of depressive behaviors[J].Sci Rep,2015,5:8415.
[21] XING Y Q,LI A,YANG Y,et al.The regulation of FOXO1 and its role in disease progression[J].Life Sci,2018,193:124-131.
[22] JING E,GESTA S,KAHN C R.SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation[J].Cell metabolism,2007,6(2):105-114.
[23] WOOD I S,DE HEREDIA F P,WANG B,et al.Cellular hypoxia and adipose tissue dysfunction in obesity[J].Proc Nutr Soc,2009,68(4):370-377.
[24] YE J.Emerging role of adipose tissue hypoxia in obesity and insulin resistance[J].Int J Obes(Lond),2009,33(1):54-66.
[25] KRISHNAN J,DANZER C,SIMKA T,et al.Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ syste[J].Genes Dev,2012,26(3):259-270.
[26] MARTIN M G,TROVO L,PERGA S,et al.Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons[J].Neurobiol Aging,2011,32(5):933-943.
[27] LUTHI-CARTER R,TAYLOR D M,PALLOS J,et al.SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis[J].Proc Natl Acad Sci U S A,2010,107(17):7927-7932.
[28] 张婵娟.NAD依赖性脱乙酰酶SIRT2参与程序性坏死[J].中国病理生理杂志,2012,492(7428):199-204.
[29] ZHANG J,WANG C,NIE H,et al.SIRT2 plays a significant role in maintaining the survival and energy metabolism of PIEC endothelial cells[J].Int J Physiol Pathophysiol Pharmacol,2016,8(3):120-127.
[30] NIE H,CHEN H,HAN J,et al.Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells[J].Int J Physiol Pathophysiol Pharmacol,2011,3(1):65-70.
[31] HE X,NIE H,HONG Y,et al.SIRT2 activity is required for the survival of C6 glioma cells[J].Biochem Biophys Res Commun,2012,417(1):468-472.
[32] JING H,HU J,HE B,et al.A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity[J].Cancer cell,2016,29(5):767-768.

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