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量子点的免疫毒性研究进展
作者:张紫钰  赵鑫尧  魏婷婷  唐萌 
单位:环境医学工程教育部重点实验室, 东南大学公共卫生学院, 江苏 南京 210009
关键词:量子点 免疫细胞 免疫毒性 
分类号:R114
出版年·卷·期(页码):2019·38·第一期(187-191)
摘要:

量子点(quantum dots,QDs)是一种新型的半导体纳米荧光材料,在生物医学等多方面得到广泛的应用。本文通过对QDs体内外免疫毒性研究的实验结果进行分析总结,讨论QDs在应用中可能存在的免疫毒性,重点阐述了QDs对巨噬细胞、树突状细胞、淋巴细胞等免疫细胞的毒性效应,例如氧化应激激活、促炎细胞因子释放和自噬等,并对QDs毒性的研究作了展望。

参考文献:

[1] 李雪梅,付大友,袁东,等.CdSe/CdS量子点的制备及光学性能研究[J].现代化工,2017,38(12):123-125.
[2] FONTANA J M,YIN H,CHEN Y,et al.Transport and release of colloidal 3-mercaptopropionic acid-coated CdSe-CdS/ZnS core-multishell quantum dots in human umbilical vein endothelial cells:[J].Int J Nanomedicine,2017,12:8615-8629.
[3] GONDA K,WATANABE T M,OHUCHI N,et al.In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots[J].J Biol Chem,2010,285(4):2750-2757.
[4] LEE J Y,JEON S,LIM J S,et al.Dual-wavelength digital holography with a low-coherence light source based on a quantum dot film[J].Opt Lett,2017,42(24):5082-5085.
[5] KHAN W U,WANG D,ZHANG W,et al.High Quantum Yield Green-Emitting Carbon Dots for Fe(Ⅲ) Detection,Biocompatible Fluorescent Ink and Cellular Imaging:[J].Sci Rep,2017,7(1):14866.
[6] 汤陌生.量子点技术及其在生物医学检验中的应用[J].中国医学装备,2016,13(3):142-144.
[7] DERFUS A M,CHAN W C W,BHATIA S N.Probing the cytotoxicity of semiconductor quantum dots[J].Nano Lett,2004,4(1):11-18.
[8] LOVRIA J,BAZZI H S,CUIEY,et al.Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots[J].J Mol Med (Berl),2005,83(5):377-385.
[9] CHEN N,HE Y,SU Y,et al.The cytotoxicity of cadmium-based quantum dots[J].Biomaterials,2012,33(5):1238-1244.
[10] BRUNEAU A,FORTIER M,GAGNE F,et al.In vitro immunotoxicology of quantum dots and comparison with dissolved cadmium and tellurium[J].Environ Toxicol,2015,30(1):9-25.
[11] 齐丽娟,李宁.免疫毒理学的评价方法及其研究进展[J].国外医学:卫生学分册,2008,35(3):174-180.
[12] 徐锋,唐丽,贺福初.免疫系统蛋白质相互作用的研究方法[J].细胞与分子免疫学杂志,2010,26(8):830-832.
[13] QU G,WANG X,ZHE W,et al.Cytotoxicity of quantum dots and graphene oxide to erythroid cells and macrophages[J].Nanoscale Res Lett,2013,8(1):198-198.
[14] 詹庆玲,唐萌,张婷,等.CdTe@MPA量子点对小鼠腹腔巨噬细胞活性的影响[J].环境与健康杂志,2014,31(2):111-113.
[15] XU X,ZHANG K,ZHAO L,et al.Aspirin-based carbon dots,A good biocompatibility of material applied for bioimaging and anti-inflammation[J].ACS Appl Mater Interf,2016,8(48):32706-32716.
[16] BUZEA C,PACHECO I I,ROBBIE K.Nanomaterials and nanoparticles:sources and toxicity[J].Biointerphases,2007,2(4):R17-R71.
[17] 李翀,严成,金慧敏,等.量子点与巨噬细胞的生物相容性[J].中国组织工程研究,2017,21(26):4217-4221.
[18] LIU J,EROGBOGBO F,YONG K T,et al.Assessing clinical prospects of silicon quantum dots:studies in mice and monkeys[J].Acs Nano,2013,7(8):7303-7310.
[19] GREE M,HOWMAN E.Semiconductor quantum dots and free radical induced DNA nicking[J].Chem Commun (Camb),2005,1(1):121-123.
[20] MANKE A,WANG L,Rojanasakul Y.Mechanisms of nanoparticle-induced oxidative stress and toxicity[J].Biomed Res Int,2013,2013:1-15.
[21] CHAN WH,SHIAO NH,LU PZ.CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrialdependent pathways and inhibition of survival signals[J].Toxicol Lett,2006,167(3):191-200.
[22] LIN G,DINGZ,HU R,et al.Cytotoxicity and immune response of CdSe/ZnS Quantum dots towards a murine macrophage cell line[J].Rsc Advances,2014,4(11):5792-5797.
[23] AFFANDI A J,CARVALHEIRO T,Radstake T,et al.Dendritic cells in systemic sclerosis:Advances from human and mice studies[J].Immunol Lett,2018,195:18-29.
[24] ZHAO Y,WANG X,WU Q,et al.Translocation and neurotoxicity of CdTe quantum dots in RMEs motor neurons in nematode Caenorhabditis elegans[J].J Hazard Mater,2015,283:480-489.
[25] 唐岩,战军,常昕莹,等.人树突状细胞摄取量子点后的表面标志与超微结构[J].解剖学杂志,2010,33(5):583-586.
[26] 王冰,王红梅,徐方云,闵卫平.树突状细胞与肿瘤免疫[J].中国细胞生物学学报,2013,35(11):1666-1671.
[27] 张引成,金晓明,刘军,等.细胞凋亡过程中细胞内Ca2+和蛋白激酶C浓度的改变[J].实用口腔医学杂志,2003,19(5):493-495.
[28] WANG X,TIAN J,YONG K T,et al.Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages,lymphocytes and BALB/c mice[J].J Nanobiotechnology,2016,14(1):10-10.
[29] PLESKOVA S N,MIKHEEVA E R,Gornostaeva E E.The interaction between human blood neutrophil granulocytes and quantum dots[J].Micron,2018,105:82-92.
[30] 卢永辉.CdSe/ZnS量子点纳米颗粒暴露的肝毒性及分子机制研究[D].武汉:第三军医大学,2016.
[31] 韦小敏,陆继培,雷珍莲,等.镉对体外培养淋巴细胞免疫毒性的研究[J].工业卫生与职业病,2006,32(4):209-211.
[32] HOSSAIN Z,HUQ F.Studies on the interaction between Cd(2+) ions and DNA[J].J Inorg Biochem,2002,90(3-4):85-96.
[33] 宋尔群,魏宏,宋杨.量子点细胞毒性效应研究进展[J].环境化学,2011,30(3):585-590.
[34] CARVALHO S M D,MANSUR A A P,MANSUR H S,et al.In vitro,and in vivo,assessment of nanotoxicity of CdS quantum dot/aminopolysaccharide bionanoconjugates[J].Mater Sci Eng C Mater Biol Appl,2017,71:412-424.
[35] NATHAN C.Neutrophils and immunity:Challenges and opportunities[J].Nat Rev Immunol,2006,6(3):173-182.
[36] HARBORT C J,SOEIRO-PEREIRA P V,VON BERNUTH H,et al.Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis[J].Blood,2015,126(26):2842-2851.
[37] FANG H,JIANG W,CHENG J,et al.Balancing innate immunity and inflammatory state via modulation of neutrophil function:A novel strategy to fight sepsis[J].J Immunol Res,2015:187048.
[38] HSIN Y H,CHEN C F,HUANG S,et al.The apoptotic effect of nanosilver is mediated by a ROS-and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells[J].Toxicol Lett,2008,179(3):130-139.
[39] KROEMER G,MARIÑO G,LEVINE B.Autophagy and the integrated stress response[J].Mol Cell,2010,40(2):280-293.
[40] 张保全,郭振辉,房巍,等.Calpain裂解Atg5决定中性粒细胞发生自噬还是凋亡,以及C5a在其中的可能作用[J].生物化学与生物物理进展,2008,35(12):1358-1363.
[41] BRUNETTI V,CHIBLI H,FIAMMENGO R,et al.InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots:in vitro and in vivo toxicity assessment[J].Nanoscale,2013,5(1):307-317.
[42] LIU J,YANG C,JING L,et al.Effects of Cd-based quantum dot exposure on the reproduction and offspring of kunming mice over multiple generations[J].Nanotheranostics,2017,1(1):23-37.
[43] 王萌萌,王吉龙,孙湖泊,孙志伟,黄沛力.碲化镉量子点Cd~(2+)释放对小鼠肝、肾组织毒作用的研究[J].生态毒理学报,2015,10(3):256-261.
[44] BRUNEAU A,FORTIER M,GAGNE F,et al.In vitro immunotoxicology of quantum dots and comparison with dissolved cadmium and tellurium[J].Environ Toxicol,2015,30(1):9-25.
[45] LIBRALATO G,GALDIERO E,FALANGA A,et al.Toxicity effects of functionalized quantum dots,gold and polystyrene nanoparticles on target aquatic biological models:A review[J].Molecules,2017,22(9):1439.
[46] SONG Y,FENG D,SHI W,et al.Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots,gold nanoparticles,and carbon nanodots on live cells as well as green gram sprouts[J].Talanta,2013,116:237-244.
[47] LIU J,HU R,LIU J,et al.Cytotoxicity assessment of functionalized CdSe,CdTe and InP quantum dots in two human cancer cell models[J].Mater Sci Eng C Mater Biol Appl,2015,57:222-231.
[48] MANIKANDAN D,BOUKHVALOV D W,AMIRTHAPANDIAN S,et al.An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots:an experimental and DFT approach[J].Phys Chem Chem Phys,2018,20(9):6500-6514.
[49] 杨林,许恒毅,魏华,熊勇华.量子点毒性机制及对生殖系统毒性的研究进展[J].生殖与避孕,2012,32(12):829-836.
[50] HORIE M,KATO H,ENDOH S,et al.Cellular effects of industrial metal nanoparticles and hydrophilic carbon black dispersion[J].J Toxicol Sci,2014,39(6):897-907.
[51] 郑凤霞,许恒毅,傅芬.小鼠孕早期暴露量子点对妊娠结局和CD4+CD25+Treg细胞的影响[J].中国现代医学杂志,2016,26(15):28-31.
[52] SARHAN O M,HUSSEIN R M.Effects of intraperitoneally injected silver nanoparticles on histological structures and blood parameters in the albino rat[J].Int J Nanomedicine,2014,9(1):1505-1517.

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