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同型半胱氨酸水平与缺血性脑卒中的相关性研究
作者:张汉卿  闫福岭 
单位:东南大学附属中大医院 神经内科, 江苏 南京 210009
关键词:同型半胱氨酸 中青年 缺血性脑卒中 短暂性脑缺血发作 
分类号:R743.33
出版年·卷·期(页码):2019·38·第一期(77-80)
摘要:

目的:探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑卒之间的关系。方法:分别测定140例缺血性脑卒中患者、100例健康对照者血浆Hcy浓度。结果:缺血性脑卒中患者血浆Hcy水平明显高于健康对照组(P<0.01),其中中青年患者血浆Hcy水平又高于老年患者(P<0.01);缺血性脑卒中不同亚型血浆Hcy水平差异无统计学意义(P>0.05)。结论:血浆高Hcy血症(Hyperhomocysteinaemia,HHcy)是缺血性脑卒中重要危险因素,尤对中青年缺血性脑卒中组的影响最为显著,血浆Hcy水平与不同脑卒中亚型无相关性。

Objective:To explore the relationship between plasma homocysteine (Hcy) level and ischemic stroke (IS). Methods:Plasma Hcy level was measured in 140 IS patients and 100 healthy controls. Results:The level of plasma Hcy in IS patients was significantly higher than that in the healthy control group (P<0.01), the plasma Hcy level in young and middle-aged patients was higher than that of old IS patients (P<0.01). There was no significant difference in plasma Hcy level in different subtypes of IS patients (P>0.05). Conclusion:Hyper-homocysteinemia (HHcy) is an independent risk factor, especially for the young and middle-aged IS patients. No correlation was found between plasma Hcy level and IS subtypes.

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