Objective:To investigate the changes and clinical significance of von Willebrand factor cleavage enzyme (vWF-cp), cathepsin K (Cat K), Cystatin C (CysC) and P selectin in peripheral blood of patients with acute coronary syndrome (ACS). Methods:Ninety ACS patients in our hospital department of cardiology diagnosed (ACS group), 90 patients with stable angina pectoris (SAP group) and 90 healthy subjects (control group), from January 2016 to July 2017, were enrolled in the study. The serum levels of vWF,Cat Ky CysCfP selectin were measured in the three groups, and the relationship between the above indexes and the number of coronary artery lesion branches and the coronary Gensini score in ACS patients was analyzed.Results:ACS group, SAP group, Cat K CysC, serum P selectin levels were significantly higher than those in the control group (P<0.05), vWF-cp was significantly lower than the control group (P<0.05); Serum Cat K, CysC, P selectin levels of ACS group were significantly higher than that of SAP group (P<0.05), vWF-cp was lower than those in SAP group (P<0.05); Cat K, CysC, P selectin levels increased gradually while vWF-cp decreased gradually in turn in single, double and three vessel disease groups (P<0.05), ACS K, CysC, Cat in serum of patients with P selectin and Gensini score showed a significant positive correlation (P<0.05), a a significant negative correlation between vWF-cp and Gensini score was also found (P<0.05).Conclusion:The serum levels of Cat K, CysC, P selectin are significantly increased and the level of vWF-cp decreased significantly in ACS patients, which is closely related to the degree of coronary artery disease. |
[1] DARDASHTI A,NOZOHOOR S,ALGOTSSON L,et al.The predictive value of s-cystatin C for mortality after coronary artery bypass surgery[J].J Thorac Cardiovasc Surg,2016,152(1):139-146.
[2] 章亚平,朱华忠,殷兆芳,等.稳定型冠心病患者血管假性血友病因子水平与心血管事件的关系[J].心血管康复医学杂志,2015,24(5):533-536.
[3] 李璐,王志荣.冠心病患者血清组织蛋白酶S浓度变化及临床意义[J].中国农村卫生,2015(22):50.
[4] 李妍,李芳,肖婷,等.冠心病患者血清胱抑素C与髓过氧化物酶、Fractalkine水平的变化及相关性[J].广东医学,2016,37(9):1311-1314.
[5] 霍小蓓,张蕴莉,刘彦彦.P-选择素基因多态性与冠心病的相关性[J].解放军医学院学报,2014,35(4):374-378.
[6] 王健.血清选择素家族检测在老年冠心病合并高血压病诊断中的临床意义[J].中国乡村医药,2014,21(22):38-39.
[7] MANOCHA A,GUPTA F,JAIN R,et al.The potential of Cystatin C and small dense LDL as biomarkers of coronary artery disease risk in a young Indian population[J].Mol Cell Biochem,2014,389(1-2):59-68.
[8] 王婧,汤成春.糖化血红蛋白A1c水平与冠心病的相关性研究进展[J].东南大学学报:医学版,2014,33(2):238-242.
[9] 闻加升,于宗良,谷慧敏,等.老年冠心病患者血清炎症因子、基质金属蛋白酶-9、尿酸、胱抑素C水平变化[J].中国老年学杂志,2016,36(21):5275-5277.
[10] 袁琳,类延娜,李玉子,等.组织蛋白酶K、胱抑素C与冠心病及其危险因素的相关性[J].中国老年学杂志,2015,35(23):6725-6727.
[11] 袁忠海,侯毅鞠,赵臣,等.冠心病患者血管性血友病因子检测的临床价值[J].临床心血管病杂志,2014,30(5):450-452.
[12] 杨军,王苏燕,文格波,等.冠心病患者血管性血友病因子裂解酶水平与GRACE评分及Gensini积分的相关性分析[J].重庆医科大学学报,2014,39(9):1325-1328.
[13] WANG G,SUN K,HU D,et al.Serum cystatin C levels are associated with coronary artery disease and its severity[J].Clin Biochem,2014,47(16-17):176-181.
[14] RUIZ-SALAS A,CORTES-RODRIGUEZ M,ALEGRE-RAYO N,et al.Relación entre cistatina C y calcificación coronaria en pacientes con riesgo cardiovascular intermedio[J].Med Clin (Barc),2014,143(12):535-538.
[15] SHEN Y,DING F H,ZHANG R Y,et al.Serum Cystatin C reflects angiographic coronary collateralization in stable coronary artery disease patients with chronic total occlusion[J].PLoS One,2015,10(9):253-255. |
