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肠道细菌与肠黏膜机械屏障损伤关系的研究进展
作者:方晶1  薛博瑜1  方南元1 2 
单位:1. 南京中医药大学, 江苏 南京 210046;
2. 江苏省中医院, 江苏 南京 210029
关键词:肠道细菌 黏液层 肠上皮细胞 紧密连接 综述 
分类号:R378.2
出版年·卷·期(页码):2018·37·第二期(330-334)
摘要:

肠道菌群紊乱、肠黏膜机械屏障功能失常与多种疾病的发生发展密切相关。饮食、环境、遗传等因素导致肠道菌群紊乱,致病菌及其代谢产物可破坏肠黏膜机械屏障,致病物质入血,进而导致多种疾病。肠黏膜机械屏障由肠上皮细胞、上皮细胞间紧密连接及覆盖于上皮细胞表面的黏液层共同构成。作者从肠道细菌影响肠黏膜机械屏障功能的角度,分别对肠道细菌及代谢产物与黏液层、肠上皮细胞及紧密连接的关系进行综述。

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