Objective: To investigate the prevalence of fatigue and its associated factors in the patients with Parkinson disease(PD). Methods: Ninety-seven patients with PD were enrolled in this research. Fatigue severity scale was used to evaluate whether the fatigue exist or not. All patients were assessed by the unified PD rating scale(UPDRS), Hoehn-Yahr stage, Beck anxiety inventory(BAI), Beck depression inventory(BDI), PD sleep scale(PDSS),PD questionnaire-39(PDQ-39) and levodopa equivalent dose(LED),and the results were comparison between the fatigue group and the non-fatigue group. Results: Of the 97 patients,63(63.9%) were defined as fatigue.UPDRS,Hoehn-Yahr stage,the scores of BAI, BDI, PDSS, PDQ-39 and LED, were associated with fatigue. Binary-Logistic regression analysis showed that the scores of BDI and PDSS were independent risk factors for fatigue in patients with PD. Conclusion: Patients with PD have high incidence of fatigue.Depression and sleep disorder are correlated with fatigue, and it significantly influences the quality of life.
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