Objective:To investigate the effects of Hedyotis diffusa willd detoxification Spleen Prescription on tumor related index and pain in patients with advanced primary liver cancer.Methods:Eighty patients with advanced primary liver cancer admitted to our hospital during May.2014 to Dec.2015 were divided into the control group and the observation group,40 in each.The control group was treated with general supportive care,and on the base,the observation group was treated with Hedyotis diffusa willd detoxification Spleen Prescription,and supplemented syndrome treating.The VAS and the serum tumor related index levels were compared between the two groups.Results:The VAS of the two groups were all significantly reduced after treatment(P<0.05),but there was no difference between the two groups(P<0.05).And after treatment,the levels of serum Alpha fetoprotein,carcinoembryonic antigen and carbohydrate antigen 199 in the observation group were significantly lower than those in control group and before treatedment (P<0.05).After treatment,the levels of serum connective tissue growth factor and vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1 alpha (HIF-1 alpha) in the observation group were significantly lower than those before treatment (P<0.05), and the observation group was significantly lower than those in control group (P<0.05).Adverse reactions of the two groups were not statistically significant (P>0.05).Conclusion:Hedyotis diffusa willd detoxification Spleen Prescription can significantly alleviate the pain of patients with advanced primary liver cancer,inhibit the proliferation of tumor cells,and there is little toxic side effects,it is safe and should be clinically widely used.
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