白花蛇舌草解毒健脾方对原发性肝癌晚期患者肿瘤相关指标及疼痛的影响-东南大学学报医学版

白花蛇舌草解毒健脾方对原发性肝癌晚期患者肿瘤相关指标及疼痛的影响

单位：川北医学院附属医院中医科, 重庆 637000

分类号：R451

出版年·卷·期（页码）：2017·36·第一期（44-47）

摘要：

目的：探讨中药白花蛇舌草解毒健脾方对原发性肝癌晚期患者肿瘤相关指标以及疼痛的影响。方法：选择2014年5月至2015年12月于我院治疗的80例原发性肝癌晚期患者，根据相近入院时间随机分为研究组和对照组，每组40例，对照组实施常规支持治疗，研究组在常规支持治疗基础上，给予自拟白花蛇舌草解毒健脾方，辅以辨证加减治疗。比较两组患者的疼痛评分（VAS）及血清肿瘤相关指标。结果：治疗后两组VAS均较治疗前显著下降（P<0.05），研究组VAS低于对照组，但差异无统计学意义（P>0.05）。治疗后研究组血清中甲胎蛋白、癌胚抗原、糖抗原199水平均显著低于治疗前及对照组（P<0.05），血清结缔组织生长因子、血管内皮生长因子及缺氧诱导因子-1α水平均显著低于治疗前及对照组（P<0.05）。两组不良反应比较，差异无统计学意义（P>0.05）。结论：白花蛇舌草解毒健脾方能够显著缓解原发性肝癌晚期患者的疼痛，抑制肿瘤细胞的增殖，且毒副作用小，安全性高，临床可推广使用。

Objective:To investigate the effects of Hedyotis diffusa willd detoxification Spleen Prescription on tumor related index and pain in patients with advanced primary liver cancer.Methods:Eighty patients with advanced primary liver cancer admitted to our hospital during May.2014 to Dec.2015 were divided into the control group and the observation group,40 in each.The control group was treated with general supportive care,and on the base,the observation group was treated with Hedyotis diffusa willd detoxification Spleen Prescription,and supplemented syndrome treating.The VAS and the serum tumor related index levels were compared between the two groups.Results:The VAS of the two groups were all significantly reduced after treatment(P<0.05),but there was no difference between the two groups(P<0.05).And after treatment,the levels of serum Alpha fetoprotein,carcinoembryonic antigen and carbohydrate antigen 199 in the observation group were significantly lower than those in control group and before treatedment (P<0.05).After treatment,the levels of serum connective tissue growth factor and vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1 alpha (HIF-1 alpha) in the observation group were significantly lower than those before treatment (P<0.05), and the observation group was significantly lower than those in control group (P<0.05).Adverse reactions of the two groups were not statistically significant (P>0.05).Conclusion:Hedyotis diffusa willd detoxification Spleen Prescription can significantly alleviate the pain of patients with advanced primary liver cancer,inhibit the proliferation of tumor cells,and there is little toxic side effects,it is safe and should be clinically widely used.

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