血小板淋巴细胞比值与中性粒细胞淋巴细胞比值在HBV、HCV感染者中的临床意义评价-东南大学学报医学版

血小板淋巴细胞比值与中性粒细胞淋巴细胞比值在HBV、HCV感染者中的临床意义评价

单位：郑州大学第一附属医院检验科, 河南省检验医学重点实验室, 河南郑州 450052

分类号：R512.6

出版年·卷·期（页码）：2016·35·第六期（854-860）

摘要：

目的：探究血小板淋巴细胞比值（PLR）和中性粒细胞淋巴细胞比值（NLR）在病毒性肝脏疾病进展及预后中临床意义。方法：回顾分析我院电子病历系统数据，依据纳入排除标准，纳入2013年1月至2015年6月来我院就诊的HBV和HCV感染相关肝脏疾病和非病毒性肝脏疾病患者共计309例和健康对照40例（HC组），肝脏疾病患者分为慢性乙型肝炎未治疗（HBV-UT）组、清除（HBV-Cl）组、未清除（HBV-UC）组、肝硬化（HBV-Cirr）组、肝癌（HBV-HCC）组，慢性丙型肝炎未治疗（HCV-UT）组、清除（HCV-Cl）组、未清除（HCV-UC）组、肝硬化（HCV-Cirr）组、肝癌（UV-HCC）组，非病毒性肝炎/肝损伤（UV-Ht）组、肝硬化（UV-Cirr）组、肝癌（UV-HCC）组，比较各组PLR和NLR差异。结果：HCV-Cl组PLR明显高于HCV-UT、HCV-UC组（P<0.05），HCV-UT、HCV-UC组NLR明显低于HC组（P<0.05）。HCV-UT、HCV-Cirr、HCV-HCC组较之HC组，PLR均显著降低，差异有统计学意义（P<0.05），并且HCV-Cirr、HCV-HCC组较之HCV-UT组PLR也降低，差异有统计学意义（P<0.05），但HCV-Cirr组与HCV-HCC组PLR无差异。结论：PLR和NLR在病毒性肝脏疾病的进展、预后中有着一定的指示作用，尤其HCV感染中，PLR与其病毒学应答和疾病进展密切相关。

Objective: To explore the clinical significance of PLR and NLR in the progression and prognosis of viral liver disease. Methods: By retrospective analysis of the electronic medical records system data,according to the inclusion and exclusion criteria,a total of 309 patients with liver disease associated with HBV infection,HCV infection or non-viral liver disease were included from January 2013 to June 2015.The group of healthy controls(HC) consisted of 40 healthy individuals.The patients were divided into HBV untreated(HBV-UT) group,HBV cleared(HBV-Cl) group,HBV uncleared(HBV-UC) group,HBV-cirrhosis(HBV-Cirr) group,HBV-hepatocellular cancer(HBV-HCC) group;HCV untreated(HCV-UT) group,HCV cleared(HCV-Cl) group,HCV uncleared(HCV-UC) group,HCV-cirrhosis(HCV-Cirr)group,HCV-hepatocellular cancer(UV-HCC) group;Virus-unrelated hepatitis/liver damage(UV-Ht) group,virus-unrelated cirrhosis(UV-Cirr) group,virus-unrelated hepatocellular cancer(UV-HCC) group.The differences of PLR and NLR in each groups were compared. Results: PLR of HCV-Cl group was obviously higher than that of HCV-UT and HCV-UC group(P<0.05),NLR of HCV-UT and HCV-UC group were lower than that of HC group(P<0.05).Compared with HC group,PLR of HCV-UT,HCV-Cirr and HCV-HCC group were significantly lower,and the differences were statistically significant(P<0.05).Compared with HCV-UT,PLR of HCV-Cirr and HCV-HCC group reduce and the differences were statistically significant(P<0.05),while PLR of HCV-Cirr and HCV-HCC group showed no difference. Conclusion: PLR and NLR have a certain indicative function in the progression and prognosis of viral liver disease,especially in patients with HCV-associated liver disease.

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