Objective:To study the changes of cystatin C(CysC), homocysteine(Hcy) and sialic acid(SA) levels in different stages of chronic kidney disease(CKD). Methods:One hundred and twenty-nine patients with CKD were selected as study subjects, of whom 31 were in CKD stage 1, 18 in stage 2, 17 in stage 3, 12 in stage 4 and 51 in stage 5, and 32 healthy persons were served as the controls. Their clinical data were collected and statistically analyzed. Results:The levels of Hcy, CysC and SA increased gradually in CKD stages, and the differences between the subject group and the control group were statistically significant. The differences of CysC between the stages were statistically significant in all stages of CKD; the differences of Hcy were statistically significant between the stage 5 of CKD and stage 1, 2 and 3, while the differences among stage 2, 3 and 4 were statistically insignificant, and the differences between stage 1 of CKD and the other 4 stages were statistically significant.The differences of SA were statistically significant between stage 5 and the other 4 stages. Spearman relativity analysis showed that Hcy, SA and CysC were negatively correlated with eGFR(r=-0.606, P=0.000;r=-0.571, P=0.000;r=-0.911, P=0.000).eGFR as the dependent variable, Logistic regression analysis showed that CysC(OR=29.816, 95%CI=7.490-118.69, P=0.000) and Hcy(OR=1.107, 95%CI=1.024-1.198, P=0.011) have statistical significance. Conclusion:CysC and Hcy are independent risk factors for the deterioration of CKD. SA has clinical significance in the diagnosis of CKD at the final stage. |
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