肝细胞肝癌TAE前后血清HIF-1α、VEGF表达与疗效的相关性研究-东南大学学报医学版

肝细胞肝癌TAE前后血清HIF-1α、VEGF表达与疗效的相关性研究

单位：1. 东南大学附属南京第二医院放射科, 江苏南京 210003;
2. 江苏省肿瘤医院放射科, 江苏南京 210009;
3. 东南大学附属南京第二医院肝胆外科, 江苏南京 210003

分类号：R735.7

出版年·卷·期（页码）：2016·35·第四期（537-540）

摘要：

Objective:To investigate the expression levels of hypoxia inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) before and after transcatheter arterial embolization (TAE) in hepatocellular carcinoma (HCC), and their correlations with therapeutic effects. Methods:Thirty-six consecutive patients fulfilling diagnostic criteria for HCC undergoing TAE from January 2015 to December 2015 were enrolled into this clinical study. The serum HIF-1α and VEGF levels of all patients were analyzed using enzyme-linked immunosorbent assay (ELISA) 1 day before-TAE, and 3 days, 1 month after-TAE. All patients were divided into complete response (CR) and partial response (PR), stable disease (SD), progressive disease (PD) groups according to the therapeutic efficacy after one month. Results:The expression levels of serum HIF-1α and VEGF in HCC patients were (136.56±69.36) and (287.83±125.74) ρg·ml^-1 before TAE respectively. Three days after TAE, both serum HIF-1α(325.15±36.21) and VEGF levels (395.17±98.36)ρg·ml^-1 reached the peak values, and were higher than those before TAE (P<0.05). The levels of HIF-1α and VEGF in CR group after one month were significantly lower than those in PR+SD+PD group (P<0.05). The level of serum HIF-1α was positively correlated with serum VEGF level (r=0.69, P<0.05). Conclusion:The serum levels of HIF-1α and VEGF were in high expression in short time after TAE in HCC. The expression of HIF-1α and VEGF was positively correlated with clinical effects.

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