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Hippo通路调控细胞增殖与凋亡的研究进展
作者:毛幸1  周晓明1  吴小涛2  洪鑫2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 脊柱外科, 江苏 南京 210009
关键词:Hippo信号通路 TAZ/YAP G-蛋白偶联受体调节因子 胚胎干细胞 综述 
分类号:R329.25
出版年·卷·期(页码):2016·35·第三期(413-417)
摘要:

经过科学家20多年的研究发现,Hippo信号通路对促进组织生长、调节器官大小起着重要的作用。该通路广泛存在于生命体中,且通过转录因子TAZ/YAP来发挥其重要的生物学功能,而TAZ/YAP又受到应力信号及G-蛋白偶联受体调节因子(GPCRs)的调节。近来有研究表明,在胚胎干细胞(ESCs)中Hippo通路也起到了关键性作用。作者将对TAZ/YAP的具体调控机制作一综述。

参考文献:

[1] 周洲,朱金水.Hippo通路及YAP基因研究的新进展[J].现代肿瘤医学,2011,19(6):1241-1244.
[2] YU F X,ZHAO B,PANUPINTHU N,et al.Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling[J].Cell,2012,150(4):780-791.
[3] ZHAO B,TUMANENG K,GUAN K L.The Hippo pathway in organ size control,tissue regeneration and stem cell self-renewal[J].Nat Cell Biol,2011,13(8):877-883.
[4] BANDURA J L,EDGAR B A.Yorkie and Scalloped:partners in growth activation[J].Dev Cell,2008,14(3):315-316.
[5] KOONTZ L M,LIU-CHITTENDEN Y,YIN F,et al.The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression[J].Dev Cell,2013,25(4):388-401.
[6] FERNANDEZ B G,GASPAR P,BRAS-PEREIRA C,et al.Actin-capping protein and the hippo pathway regulate F-actin and tissue growth in Drosophila[J].Development,2011,138(11):2337-2346.
[7] SUDOL M.Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product[J].Oncogene,1994,9(8):2145-2152.
[8] SHIMOMURA T,MIYAMURA N,HATA S,et al.The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity[J].Biochem Biophys Res Commun,2014,443(3):917-923.
[9] SALAH Z,ALIAN A,AQEILAN R I.WW domain-containing proteins:retrospectives and the future[J].Front Biosci,2012,17:331-348.
[10] WEBB C,UPADHYAY A,GIUNTINI F,et al.Structural features and ligand binding properties of tandem WW domains from YAP and TAZ,nuclear effectors of the Hippo pathway[J].Biochemistry,2011,50(16):3300-3309.
[11] ERNST A,APPLETON B A,IVARSSON Y,et al.A structural portrait of the PDZ domain family[J].J Mol Biol,2014,426(21):3509-3519.
[12] OUDHOFF M J,FREEMAN S A,COUZENS A L,et al.Control of the hippo pathway by Set7-dependent methylation of Yap[J].Dev Cell,2013,26(2):188-194.
[13] JANG E J,JEONG H,HAN K H,et al.TAZ suppresses NFAT5 activity through tyrosine phosphorylation[J].Mol Cell Biol,2012,32(24):4925-4932.
[14] CALVO F,EGE N,GRANDE-GARCIA A,et al.Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts[J].Nat Cell Biol,2013,15(6):637-646.
[15] ROSENBLUH J,NIJHAWAN D,COX A G,et al.β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis[J].Cell,2012,151(7):1457-1473.
[16] LEVY D,ADAMOVICH Y,REUVEN N,et al.Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage[J].Mol Cell,2008,29(3):350-361.
[17] TIAN W,YU J,TOMCHICK D R,et al.Structural and functional analysis of the YAP-binding domain of human TEAD2[J].Proc Natl Acad Sci USA,2010,107(16):7293-7298.
[18] HAU J C,ERDMANN D,MESROUZE Y,et al.The TEAD4-YAP/TAZ protein-protein interaction:expected similarities and unexpected differences[J].Chembiochem,2013,14(10):1218-1225.
[19] BASU S,TOTTY N F,IRWIN M S,et al.Akt phosphorylates the Yes-associated protein,YAP,to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis[J].Mol Cell,2003,11(1):11-23.
[20] HOWELL M,BORCHERS C,MILGRAM S L.Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription[J].J Biol Chem,2004,279(25):26300-26306.
[21] ZHAO B,LI L,TUMANENG K,et al.A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)[J].Genes Dev,2010,24(1):72-85.
[22] TIAN Y,KOLB R,HONG J H,et al.TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex[J].Mol Cell Biol,2007,27(18):6383-6395.
[23] HUANG W,LV X,LIU C,et al.The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFbeta-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition[J].J Biol Chem,2012,287(31):26245-26253.
[24] AZZOLIN L,ZANCONATO F,BRESOLIN S,et al.Role of TAZ as mediator of Wnt signaling[J].Cell,2012,151(7):1443-1456.
[25] POON C L C,ZHANG X,LIN J I,et al.Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth[J].Curr Biol,2012,22(17):1587-1594.
[26] BJARNADÖ TTIR T K,GLORIAM D E,HELLSTRAND S H,et al.Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse[J].Genomics,2006,88(3):263-273.
[27] MO J S,YU F X,GONG R,et al.Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)[J].Genes Dev,2012,26(19):2138-2143.
[28] KIM M,KIM M,LEE S,et al.cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes[J].EMBO J,2013,32(11):1543-1555.
[29] DUPONT S,MORSUT L,ARAGONA M,et al.Role of YAP/TAZ in mechanotransduction[J].Nature,2011,474(7350):179-183.
[30] ARAGONA M,PANCIERA T,MANFRIN A,et al.A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors[J].Cell,2013,154(5):1047-1059.
[31] MCBEATH R,PIRONE D M,NELSON C M,et al.Cell shape,cytoskeletal tension,and RhoA regulate stem cell lineage commitment[J].Dev Cell,2004,6(4):483-495.
[32] HONG J H,HWANG E S,MCMANUS M T,et al.TAZ,a transcriptional modulator of mesenchymal stem cell differentiation[J].Science,2005,309(5737):1074-1078.
[33] TANG Y,ROWE R G,BOTVINICK E L,et al.MT1-MMPdependent control of skeletal stem cell commitment via a beta1-integrin/YAP/TAZ signaling axis[J].Dev Cell,2013,25(4):402-416.
[34] YOUNG R A.Control of the embryonic stem cell state[J].Cell,2011,144(6):940-954.
[35] BEYER T A,WEISS A,KHOMCHUK Y,et al.Switch enhancers interpret TGF-β and hippo signaling to control cell fate in human embryonic stem cells[J].Cell Rep,2013,5(6):1611-1624.
[36] WEISS A,ATTISANO L.The TGFbeta superfamily signaling pathway.Wiley interdisciplinary reviews[J].Dev Biol,2013,2(1):47-63.
[37] VARELAS X,SAKUMA R,SAMAVARCHI-TEHRANI P,et al.TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal[J].Nat Cell Biol,2008,10(7):837-848.
[38] LIAN I,KIM J,OKAZAWA H,et al.The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation[J].Genes Dev,2010,24(11):1106-1118.
[39] TAKAHASHI K,YAMANAKA S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors[J].Cell,2006,126(4):663-676.
[40] QIN H,BLASCHKE K,WEI G,et al.Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming[J].Hum Mol Genet,2012,21(9):2054-2067.
[41] 马军,孙崇毅,刘庆鹏,等.BMP9在脊柱融合过程中的作用及其相关机制研究进展[J].现代医学,2014,42(6):703-706.
[42] ALARCÖ N C,ZAROMYTIDOU A I,XI Q,et al.Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways[J].Cell,2009,139(4):757-769.
[43] 何正言,梅浩.Hippo-YAP信号通路在人膝骨性关节炎中表达的意义[J].中国实用医药,2013,8(15):24-25.
[44] 朱忠胜,张春林,汪泱.Hippo信号通路作用分子在人骨肉瘤及骨肉瘤干细胞中的表达[J].中国骨与关节杂志,2014,3(2):130-134.

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