帕金森病是一种十分常见的神经系统退行性疾病,其发病机制至今尚不明确。目前,帕金森病的治疗以口服药物补充脑内多巴胺为主,但长期服用药物治疗后临床效果可能减弱,且会产生严重的运动并发症。因此,学者们考虑通过移植多巴胺能神经组织的方法,来补充帕金森病患者脑内所缺失的多巴胺能神经元。嗅鞘细胞具有独特的生物学特性,且对中枢神经系统疾病具有较好的治疗作用,已成为当下研究的热点。作者将嗅鞘细胞移植治疗帕金森病的相关研究作一综述。

[1] LANG A E,ELDAD M,WERNER P,et al.Trial designs used to study neuroprotective therapy in Parkinson's disease[J].Mov Disord,2013,28(1):86-95.
[2] 孟凛冽,李峰,伞勇智,等.帕金森病氧化应激机制及抗氧化药物治疗进展[J].现代生物医学进展,2015,15(2):380-383.
[3] 吴毅.帕金森病治疗最新进展[J].中外医疗,2015(10):193-194.
[4] WOODHALL E,WEST A K,CHUAH M I.Cultured olfactory ensheathing cells express nerve growth factor,brain-derived neurotrophic factor,glia cell line-derived neurotrophic factor and their receptors[J].Mol Brain Res,2001,88(1):203-213.
[5] EKBERG J A,AMAYA D,MACKAY-SIM A,et al.The migration of olfactory ensheathing cells during development and regeneration[J].Neurosignals,2012,20(3):147-158.
[6] KALINCIK T,CHOI E F,BIANCO J,et al.Olfactory ensheathing cells reduce duration of autonomic dysreflexia in rats with high spinal cord injury[J].Auton Neurosci,2010,154(1-2):20-29.
[7] KOCSIS J D,LANKFORD K L,MASANORI S,et al.Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury[J].Neurosci Lett,2009,456(456):137-142.
[8] TAKEOKA A,MARC D,KUBASAK,ZHONG H,et al.Serotonergic innervation of the caudal spinal stump in rats after complete spinal transection:effect of olfactory ensheathing glia[J].J Comp Neurol,2009,515(6):664-676.
[9] LI Y,FIELD P M,RAISMAN G.Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells[J].Science 1997,277(5334):2000-2002.
[10] SHUKLA S,CHATURVEDI R K,AGRAWAL A K.Enhanced survival and function of neural stem cells-derived dopaminergic neurons under influence of olfactory ensheathing cells in parkinsonian rats[J].J Neurochem,2009,109(2):436-451.
[11] SHUKLA A,MOHAPATRA T M,PARMAR D,et al.Neuroprotective potentials of neurotrophin rich olfactory ensheathing cell's conditioned media against 6OHDA induced oxidative damage[J].Free Radical Res,2014,48(5):560-571.
[12] LEI F,MENG H,WU F,et al.Olfactory ensheathing cells conditioned medium prevented apoptosis induced by 6-OHDA in PC12 cells through modulation of intrinsic apoptotic pathways[J].Int J Dev Neurosci,2008,26(3-4):323-329.
[13] JOHANSSON S,LEE I H,SPENGER C.Olfactory ensheathing glial co-grafts improve functional recovery in rats with 6-OHDA lesions.Brain,2005,128(12):2961-2976.
[14] AGRAWAL A K,SHUKLA S,CHATURVEDI R K,et al.Olfactory ensheathing cell transplantation restores functional deficits in rat model of Parkinson's disease:a cotransplantation approach with fetal ventral mesencephalic cells[J].Neurobiol Dis,2004,16(3):516-526.