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SIRT1与间充质干细胞衰老
作者:朱厚毅1  周凡1  刘剑书1  王运涛2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 脊柱外科, 江苏 南京 210009
关键词:沉默调节因子2相关酶1 乙酰化 间充质干细胞 衰老 文献综述 
分类号:R681
出版年·卷·期(页码):2016·35·第二期(281-283)
摘要:

间充质干细胞(MSCs)是一种具有自我更新功能并可以分化为执行特定功能的体细胞,研究已经证实在体外培养的过程中MSCs会出现衰老的现象。哺乳动物沉默调节因子2相关酶1(SIRT1)是一类依赖于烟酰胺腺嘌呤二核苷酸(NAD+)的组蛋白去乙酰化酶,越来越多的研究表明, SIRT1可以通过调控P53、组蛋白乙酰化、NF-κb和FoxO等关键分子的表达,进而参与调控细胞的衰老、凋亡、代谢等生理活动。作者就SIRT1在MSCs衰老中的作用作一综述。

参考文献:

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