真核细胞以一种复杂而高效的膜转运网络维持细胞内外物质循环和新旧更替。Rab蛋白做为全局性调节因子,参与从膜发生、成熟到膜融合的几乎所有步骤,将各种膜转运形式如内吞和自噬等联系在一起。内吞能够调节细胞表面分子的分布和功能状态,而进入胞浆的蛋白可经由内吞体循环,或者在自噬小体作用下被降解利用,辅助细胞度过饥饿、缺氧等危机。基质金属蛋白酶(MMPs)在细胞表面的分布和活性受到内吞调节,并且MMPs在细胞内循环和运输与Rab蛋白关系密切。在本文作者简要回顾细胞内吞和自噬的内在关联,阐述膜结构变动对MMPs分布和功能状态的调节作用。

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