肝脏在危重病发生发展过程中起重要作用,它参与机体反应,清除体内有害的因子和产物.危重病及其治疗方式,包括脓毒症、休克、药物和肠外营养等,容易诱导肝损伤.因此,危重病引起的肝损伤是病情加重的重要环节.然而,危重病患者肝损伤的病情评估和诊断治疗仍然比较困难,可能是由于缺乏特异性的诊断评估工具和临床上对肝损伤的认识不足.作者对危重病肝损伤的定义、诊断评估指标、发病机制等方面的研究进展作一综述.

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