硝酸甘油影响兔脑动脉血流的实验研究-东南大学学报医学版

硝酸甘油影响兔脑动脉血流的实验研究

单位：1. 东南大学医学院, 江苏南京 210009;
2. 东南大学附属中大医院超声科, 江苏南京 210009

分类号：R-332;R972.3

出版年·卷·期（页码）：2015·34·第六期（1005-1008）

摘要：

目的:通过应用彩色多普勒血流显像(CDFI)检测家兔服用硝酸甘油(NTG)前后颈总动脉血流变化,探讨NTG对脑血流的影响.方法:选取健康成年家兔15只,麻醉后先用CDFI测定颈总动脉内径和基础的血流动力学参数,然后给予NTG,并在1 h内每隔5 min重复测定颈总动脉内径和血流动力学参数.对各个时间点的检测数据进行对比分析,并进行统计学处理.结果:与服用NTG前相比,服用NTG后的各时间点颈总动脉内径未见明显变化(P>0.05),PSV、EDV、TAMAX、PI、RI均呈先降低后回升,逐渐恢复至基础状态的表现,5 min左右达最低水平,瞬时血流量也发生同步的变化.结论:服用NTG不影响家兔颈总动脉内径,但可使脑血流量有相应的短暂性降低.

Objective: To explore the effect of nitroglycerin(NTG)on cerebral blood flow. Methods: In 15 anesthetized healthy adult rabbits, the diameter(D) and blood flow hemodynamic parameters of right common carotid artery(CCA) were measured by color doppler flow imaging (CDFI)before and after NTG administration. The measuring timing of post-administration were 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55 and 60 min. All data were compared and analyzed. Results: Compared with the basal level in the absence of nitroglycerin, the D in every point did not change(P> 0.05), PSV, EDV, TAMAX, PI, RI, Q were decreased sharply at first 5min, and then recovered to basic performance within the following 35 min gradually. Conclusion: After NTG administration, the D of CCA is unchanged in rabbits, the blood flow is decreased, which indicate that the cerebral blood flow has a corresponding transient decline.

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