>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
结肠癌干细胞疫苗研究与展望
作者:郭玫  窦骏 
单位:东南大学医学院 病原生物学与免疫学系, 江苏 南京 210009
关键词:结肠癌 癌干细胞 肿瘤疫苗 治疗靶标 文献综述 
分类号:R735.35;R730.3
出版年·卷·期(页码):2015·34·第二期(316-319)
摘要:

结肠癌干细胞(CSCs)参与癌症发生发展并在其中扮演重要角色,被认为是结肠癌治疗的潜在靶点.结肠癌疫苗具有疗效高、特异性强、不良反应小等优点,而结肠癌CSCs疫苗则具有更强的免疫原性、更高的靶向性和治疗效果,已成为结肠癌疫苗研究的关注点.

参考文献:

[1] SIEGEL R,MA J,ZHAOHUI Z,et al.Cancer statistics[J].CA Cancer J Clin,2014,64(1):9-29.
[2] ERIC R F.Colon and Rectal Cancer[M]//MENDELSOHN J.The Molecular Basis of Cancer.Fourth Edition.New York:Saunders,2014:499-514.
[3] JANSEN L,KOCH L,BRENNER H,et al.Quality of life among long-term(> 5 years) colorectal cancer survivors-systematic review[J].Eur J Cancer,2010,46(16):2879-2888.
[4] MARIOTTO A B,ROWLAND J H,RIES L A,et al.Multiple cancer prevalence:a growing challenge in long-term survivorship[J].Cancer Epidemiol Biomarkers Prev,2007,16(3):566-571.
[5] 林洪池,石欣.腹腔镜结肠癌根治术的现状及进展[J].东南大学学报:医学版,2013,32(6):790-792.
[6] ERNING F,STEENBERGEN L,LEMMENS V,et al.Conditional survival for long-term colorectal cancer survivors in the Netherlands:who do best[J].Eur J Cancer,2014,50(10):1731-1739.
[7] 杨廷翰.快速流程在结肠癌围术期管理中的应用价值[J].东南大学学报:医学版,2011,30(4):554-557.
[8] MUHAMMAD A H,MAX S,ADALBERTO B,et al.Prospective identification of tumorigenic breast cancer cells[J].Proc Natl Acad Sci USA,2003,100(7):3983-3988.
[9] KIM Y,WU Q,HAMERLIK P,et al.Aptamer identification of brain tumor initiating cells[J].Cancer Res,2013,73(15):4923-4936.
[10] MASAKI M,SHIORI E,KIKUMI O,et al.Identification of tumor-initiating cells in a canine hepatocellular carcinoma cell line[J].Res Vet Sci,2014,96(2):315-322.
[11] ALEXANDRA P,GEORG L,MICHAEL K,et al.Stem cells in colon cancer[J].Clin Colorectal Cancer,2008,7(2):92-98.
[12] JUERGEN K.Mechanisms of asymmetric stem cell division[J].Cell,2008,132(4):583-597.
[13] MANSOOREH S.Human embryonic stem cell science and policy:The case of Iran[J].Soc Sci Med,2013,98(2):345-350.
[14] FURSTENBERG R J,BUCZACKI S J,SMITH B J,et al.Side population sorting separates subfractions of cycling and non-cycling intestinal stem cells[J].Stem Cell Res,2014,12(2):364-375.
[15] GIAMPIERI R,SCARTOZZI M,LORETELLI C.Cancer stem cell gene profile as predictor of relapse in high risk stage Ⅱ and stage Ⅲ,radically resected colon cancer patients[J].PLoS One,2013,8(9):e72843.
[16] GERGER A,ZHANG W,YANG D.Common cancer stem cell gene variants predict colon cancer recurrence[J].Clin Cancer Res,2011,17(21):6934-6943.
[17] MATILDE T,MIRIAM G,VERONICA C,et al.CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis[J].Cell Stem Cell,2014,14(13):342-356.
[18] BOSTAD M,KRISTIAN B,ANDERS H,et al.Photochemical internalization (PCI) of immunotoxins targetingCD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties[J].J Control Release,2013,168(3):317-326.
[19] TREVOR G,ANNE E P,PAIGE S D,et al.Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract[J].Gastroenterology,2010,139(6):2072-2082.
[20] HOU Y,LIU Y Y,ZHAO X K.Expression of aldehyde dehydrogenase 1 in colon cancer[J].Asian Pac J Trop Med,2013,6(7):574-577.
[21] WU C,XIE Y Y,GAO F,et al.Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cellmarkers[J].Gene,2013,525(1):18-25.
[22] 陈克力,梁后杰,江恒,等.人HCT116结肠癌细胞系中CD133+结肠癌干细胞分离及鉴定[J].第三军医大学学报,2009,31(4):330-333.
[23] DUARTE S,MOMIER D,BAQUE P,et al.Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model[J].Stem Cells,2013,31(3):423-432.
[24] KRESO A,GALEN P,PEDLEY N M,et al.Self-renewal as a therapeutic target in human colorectal cancer[J].Nat Med,2014,20(1):29-36.
[25] KIM J H,YOON S Y,KIM C N,et al.The BMI-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins[J].Cancer Lett,2004,203(2):2-24.
[26] TODARO M,ASARO M,CACCAMO N,et al.Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes[J].J Immunol,2009,182:7287-7296.
[27] NING N,PAN Q,ZHENG F,et al.Cancer stem cell vaccination confers significant anti-tumor immunity[J].Cancer Res,2012,72(7):1853-1864.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 411829 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364