Objective  To explore the effect of early intervention on high  risk neonate development at early infancy.Methods  Compared with control group,the high  risk neonate in experimental group was trained by their trained parent every day using early intervention designed by us.The physical growth and the behavior development signs of two groups were evaluated at 3,6 month respectively.Results  Analysis demonstrated no significant differences in weight, height and head circumference between the two groups.But experimental group had significantly higher DQ than control group except language DQ at 3 month.Conclusion  Early intervention can improve behavior development of high  risk neonates.But it cant enhance their physical growth.