Septic shock, a severe clinic syndrome, is induce d by a several of pat hogens, especially gram-negative bacteria, of which the mortality is still hi gh. Toll-like receptors (TLR), pathogen-recognized receptors, are located on su rfac e of innate immune cells. TLRs play an important role in identifying pathogen, transferring signals and activating immune response. During signal transduction , TLRs activate NFκB, upregulate cytokines, such as TNF and IL-1, and enhanc e in flammatory response which kill the pathogens. However, hyper-responses of infl ammation result in organs injury. |
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