黏蛋白MUC2、MUC5AC在大肠腺癌中的表达及其临床意义-东南大学学报医学版

黏蛋白MUC2、MUC5AC在大肠腺癌中的表达及其临床意义

单位：南京医科大学附属南京第一医院,病理科,江苏,南京,210006

分类号：R735.35, R735.37, R-33

出版年·卷·期（页码）：2006·25·第五期（379-382）

摘要：

目的:探讨黏蛋白MUC2、MUC5AC在大肠腺癌中的表达情况及其临床意义.方法:采用S-P免疫组织化学法对20例正常大肠黏膜和64例大肠腺癌组织中MUC2、MUC5AC蛋白的表达情况进行检测.结果:64例大肠腺癌中MUC2、MUC5AC蛋白的阳性表达率分别为59.4%和60.9%,与正常大肠黏膜标本相比较,两者差异具有统计学意义;MUC2、MUC5AC蛋白的阳性表达均与大肠腺癌的Dukes分期和淋巴结转移有关.结论:MUC2蛋白表达下调或MUC5AC蛋白表达上调可能参与了大肠腺癌的发生、发展过程,与肿瘤的浸润转移有关.

Objective To investigate the expression and clinical significance of MUC2 and MUC5AC protein in colorectal carcinoma.Methods Immunohistochemical technique(S-Pmethod)was used to detect the expression of MUC2 and MUC5AC protein in 20 cases of normal colorectal mucosa and 64 cases of colorectal carcinoma.Results The positive rate of MUC2 and MUC5AC protein in colorectal carcinoma were 59.4% and 60.9%,respectively.Compared with normal colorectal mucosa,differences were remarkable.A strong correlation was found between MUC2,MUC5AC protein positive expression and Dukes stage,lymphonode metastasis of colorectal carcinoma.Conclusion Down-regulation of MUC2 protein or up-regulation of MUC5AC protein may participate in the pathogenesis of colorectal carcinoma and be related to the invasion and metastasis of carcinoma.

参考文献：

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